Naula C, Parsons M, Mottram JC (2005) Protein kinases as drug targets in trypanosomes and Leishmania . Biochim Biophys Acta 1754(1–2):151–9 CentralNaula, C., Parsons, M., Mottram, J.: Protein kinases as drug targets in trypanosomes and Leishmania . Biochim. Biophys. Acta. 1754...
protein kinases as drug targetsfunctional cell-based assays for GSK-3 inhibitionin vitro protein kinase activity assaysSummary This chapter contains sections titled: Protein Kinases as Drug Targets GSK-3 Inhibitors as Therapeutic Agents In Vitro Protein Kinase Activity Assays Functional Cell-Based Assays...
Protein Kinases as Drug Targets Reversible protein phosphorylation is a fundamental regulatory mechanism underlying diverse biochemical and cellular processes in eukaryotic organisms [1]. Protein kinases catalyze transfer of the γ-phosphate from ATP to protein substrates. A plethora of evidence suggests tha...
The success of drugs such as imatinib has made protein kinases an intensively studied class of drug targets. Research on new protein kinase targets and a range of potential disease indications has led to increasing interest in the development of small-molecule kinase inhibitors for the treatment of...
[3,27–32]. A perhaps instructive counterpoint to this view is the case of protein kinases: They were also considered to be challenging to target until a few decades ago. This opinion was based on the high homology of the enzymatic site and the potent binding of the natural binder. These...
Protein kinases: drug targets for immunological disorders Article 15 May 2023 Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1 Article 10 October 2022 References Yuan, J., Amin, P. & Ofengeim, D. Necroptosis and RIPK1-mediated ...
Structure-based drug discovery is routinely applied to soluble targets such as proteases and kinases. It is only recently that multiple high-resolution X-r... M.Congreve,C.Langmead,FH.Marshall - 《Advances in Pharmacology》 被引量: 120发表: 2011年 Protein kinase biochemistry and drug discovery...
Cyclin-dependent kinases (CDKs) have been extensively examined as the drug targets for cancer therapy, mainly due to their roles in controlling eukaryotic cell division and proliferation, DNA repair, differentiation as well as apoptosis [69]. Although many CDK inhibitors have shown promising anticance...
Inhibition of proteins other than the intended target by small molecules can lead to the incorrect assignment of biological functions to particular proteins and wasted drug development efforts. Potential inhibition of off-target kinases by kinase inhibit
(2005) Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes . Biochim Biophys Acta 1754 : 132–150.Doerig C, Billker O, Pratt D, Endicott J. Protein kinases as targets for antimalarial intervention: ...