A protein kinase inhibitor, fasudil (AT-877); a novel approach to signal transduction therapy. Cardiovascular Drug Rev. 16, 76–87 (1998). Article CAS Google Scholar Davies, S. P., Reddy, H., Caivano, M. & Cohen, P. Specificity and mechanism of action of some commonly used protein...
designimatinibkinase inhibitorsnilotinibX-ray crystal structureSummary This chapter covers design and development of protein kinase inhibitor drugs such as imatinib, nilotinib, bafetinib, and dasatinib for the treatment of chronic myelogenous leukemia. The chapter provides detailed SAR and structural ...
(2003) The selective tyrosine kinase inhibitor, STI571, inhibits growth of anaplastic thyroid cancer cells. J Clin Endocrinol Metab 88: 1889–1896 Article CAS Google Scholar Dziba JM and Ain KB (2004) Imatinib mesylate (Gleevec; STI571) monotherapy is ineffective in suppressing human anaplastic...
‘Crossover’ of the two structures produces the dual inhibitor 46 (IC50 MMP-1=25 nM; IC50 Cat L=15 nM); the dashed lines indicate the common core of all three molecules. 3.40.5.2 Kinase Inhibitors Kinases play a most important role in cell signaling. More than 500 different kinases are...
One example of a type IV inhibitor is GNF-2, an antagonist of BCR–Abl, which binds to the Type VI inhibitors Type VI inhibitors are those drugs that bind covalently to their protein kinase target (Table 2). Afatinib and ibrutinib are currently FDA-approved drugs that form a covalent bond...
H-89dihydrochloride是一种环腺苷酸依赖性protein kinase A抑制剂,IC50值为48nM;同时能够轻微抑制PKG,PKC,Casein Kinase等激酶活性。 注:本品仅可用于科研实验,严禁用于临床医疗及其他用途! CAS号:130964-39-5 别名:Protein kinase inhibitor H-89 dihydrochloride ...
英文名称:Protein Kinase A Inhibitor (6-22),amide 外观:粉末 CAS编号: 121932-06-7 别名:蛋白酶A圄制剂6-22酰胺 纯度:95%, 98% 用途:南京肽业 Protein Kinase A Inhibitor (6-22),amide|蛋白酶A抑制剂6-22酰胺|121932-06-7 由南京肽业特惠供应中,南京提供 Protein Kinase A Inhibitor (6-22),ami...
英文名称:Protein Kinase Inhibitor Peptide 品牌厂商性质产地货期 MedChemExpress (MCE)生产商美国现货 性能特点 蛋白激酶抑制剂 (PKIs) 是一类作为PKA的假底物的蛋白,通过结合 PKA 的催化亚基,阻断其激酶活性,调节 PKA 介导的信号事件的程度和持续时间。 PKI 家族包括 3 个编码小而热稳 ...
产品货号 15996-1 产品报价 ￥询价/1mg 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868 产品新闻 背景资料 PKI PKA Inhibitor (5-24) is a synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM) derived from...
IRAK-4 protein kinase inhibitor 2 是一种白介素 1 (IL-1) 受体相关激酶 4 (IRAK-4) 抑制剂,IC50值为4 μM。 产品性质 英文别名(English Synonym) IRAK-4 protein kinase inhibitor 2 中文名称(Chinese Name) / 靶点(Target) / 通路(Pathway) ...