progenitor exhausted T cell, Tpex分享到: 耗竭前体细胞分类: 生物学词汇 | 查看相关文献(pubmed) | 免费全文文献 详细解释: 叶丽林团队及Rafi Ahmed,Di Yu等研究团队在2016年分别独立发现, 慢性病毒感染中,位于淋巴组织内的耗竭程度较低的CXCR5+TCF-1+ Tim3-CD8+T细胞作为耗竭前体细胞(progenitor exhausted T...
The durability of an antitumor immune response is mediated in part by the persistence of progenitor exhausted CD8+T cells (Tpex). Tpex serve as a resource for replenishing effector T cells and preserve their quantity through self-renewal. However, it is unknown how T cell receptor (TCR) ...
The durability of an antitumor immune response is mediated in part by the persistence of progenitor exhausted CD8+T cells (Tpex). Tpex serve as a resource for replenishing effector T cells and preserve their quantity through self-renewal. However, it is unknown how T cell receptor (TCR) enga...
Recently, a progenitor-like CD8 T cell population with self-renewal capacity has attracted much attention, as it resembles exhausted cells, expresses CXCR5, and gives rise to effector CD8 T cells.41,42,43,44,45 Since the TLCPlo/int cells also expressed markers such as CXCR5, BCL-6, and ...
KILLER cellsIn chronic infections and cancer, exhausted CD8 T cells exhibit heterogeneous subpopulations. TCF1 PD-1 progenitor exhausted CD8 T cells (Tpex) can selfrenew and give rise to Tim-3 PD-1 terminally differentiated CD8 T cells that retain their effector function...
These Tpex cells are notable for their remarkable self-renewal and rapid proliferation abilities. Recent strides in immunotherapy have demonstrated that Tpex cells expand and differentiate into responsive exhausted CD8^(+) T cells, thus underscoring their critical role in the immunotherapeutic retort. ...
Here, we perform single-cell RNA -sequencing of tumors from patients with ESCC undergoing neoadjuvant ICB, revealing a subset of exhausted CD8+ T cells expressing SPRY1 (CD8+ Tex-SPRY1) that displays a progenitor exhausted T cell (Tpex) pheno-type and correlates with complete response to ICB...