The durability of an antitumor immune response is mediated in part by the persistence of progenitor exhausted CD8+T cells (Tpex). Tpex serve as a resource for replenishing effector T cells and preserve their quantity through self-renewal. However, it is unknown how T cell receptor (TCR) ...
The durability of an antitumor immune response is mediated in part by the persistence of progenitor exhausted CD8+T cells (Tpex). Tpex serve as a resource for replenishing effector T cells and preserve their quantity through self-renewal. However, it is unknown how T cell receptor (TCR) enga...
During chronic viral infection, CD8+ T cells develop into three major phenotypically and functionally distinct subsets: Ly108+TCF-1+ progenitors, Ly108−CX3CR1− terminally exhausted cells and the recently identified CX3CR1+ cytotoxic effector cells.
(F) GSEA of genes that are down-regulated in comparison of effector CD8 T cells versus exhausted CD8 T cells in chronic LCMV infection. Genes from the left to right in the rank-ordered list are enriched in WT and MAP4K1−/− groups, respectively. ∗p < 0.05, ∗∗p < 0.01,...
41,42,43,44,45 Since the TLCPlo/int cells also expressed markers such as CXCR5, BCL-6, and TCF-1 and had high expression of co-inhibitory receptors (activated, exhausted-like), we tested whether these cells are the CD4 T cell analogs of the progenitor-like CXCR5+ CD8 T cells. ...
Interestingly, IL1β significantly enhanced the self-renewal capacity of Tet2-KO LSKs relative to vehicle-treated Tet2-KO cells in a serial re-plating assay with increased CFU-GMs or CFU-Ms up to the quaternary plating (Fig. 2d). In contrast, WT LSKs were exhausted by the tertiary ...
TCF1 PD-1 progenitor exhausted CD8 T cells (Tpex) can selfrenew and give rise to Tim-3 PD-1 terminally differentiated CD8 T cells that retain their effector functions. Tpex cells are thus essential to maintaining a pool of antigen-specific CD8 T cells during persi...
Here, we perform single-cell RNA -sequencing of tumors from patients with ESCC undergoing neoadjuvant ICB, revealing a subset of exhausted CD8+ T cells expressing SPRY1 (CD8+ Tex-SPRY1) that displays a progenitor exhausted T cell (Tpex) pheno-type and correlates with complete response to ICB...
Progenitor exhausted CD8^(+)T cellsTCF-1IMMUNOTHERAPYtumor microenvironmentcellular crosstalkIn exploring persistent infections and malignancies, a distinctive subgroup of CD8^(+) T cells, progenitor exhausted CD8^(+) T(Tpex) cells, has been identified. These Tpex cells are notable for their ...
Single cell multi-omics reveals early elevated function and multiple fates within human progenitor exhausted CD8+ T cellsT-cell exhaustion is a hallmark of hepatitis C virus (HCV) infection and limits protective immunity in chronic viral infections and cancer. Limited knowledge exists of the initial...