The durability of an antitumor immune response is mediated in part by the persistence of progenitor exhausted CD8+T cells (Tpex). Tpex serve as a resource for replenishing effector T cells and preserve their quantity through self-renewal. However, it is unknown how T cell receptor (TCR) ...
During chronic viral infection, CD8+ T cells develop into three major phenotypically and functionally distinct subsets: Ly108+TCF-1+ progenitors, Ly108−CX3CR1− terminally exhausted cells and the recently identified CX3CR1+ cytotoxic effector cells.
The durability of an antitumor immune response is mediated in part by the persistence of progenitor exhausted CD8+T cells (Tpex). Tpex serve as a resource for replenishing effector T cells and preserve their quantity through self-renewal. However, it is unknown how T cell receptor (TCR) enga...
Dendritic cells (DCs) are critical in both initiating adaptive immune responses and maintaining tolerance to self antigens. These apparently contradictory ... D Traver,K Akashi,M Manz,... - 《Science》 被引量: 1207发表: 2000年 CD4 and CD8 regulate interleukin 2 responses of T cells. Dendriti...
Apoptotic death of CD8+ T cells can be induced by a population of inhibitory myeloid cells that are double positive for the CD11b and Gr-1 markers. These cells are responsible for the immunosuppression observed in pathologies as dissimilar as tumor growth and overwhelming infections, or after imm...
Expansion of cells with a CD45RAphenotype (thymus-derived T cells) predominated; from 3 to 6 months the increase of CD4/CD45RAT cells was 130-fold, that of CD4/CD45ROcells was 1.7-fold; CD8/CD45RAcells increased 9-fold, CD8/CD45ROcells increased 2.1-fold, indicating effective thymo...
For lymphocyte subsets, all of the absolute CD3+, CD4+, CD8+ counts and T helper: suppressor ratio were higher than those of adult blood. All of the hematopoietic progenitor cells in cord blood were also higher than in adult blood. The mean volume of cord blood for each collection was ...
• Untouched, viable cells Components: EasySep™ Human Progenitor Cell Enrichment Kit (Catalog #19056) EasySep™ Human Progenitor Cell Enrichment Cocktail, 1 mL EasySep™ Magnetic Particles, 2 x 1 mL RoboSep™ Human Progenitor Cell Enrichment Kit with Filter Tips (Catalog #19056RF) EasySep...
T lymphocytes, components of the immune and inflammatory systems, are involved in such normal processes as wound healing and host defense against infection... S Eugenio,B Mary Susan,W Craig,... - 《Circulation》 被引量: 346发表: 2003年 CD8+ T lymphocytes regulate the arteriogenic response ...
Previous data indicate that high mobility group box 1(HMGB1) facilitates MDSC differentiation from bone marrow, suppresses NK cells, CD4+ and CD8+ T cells and is involved in cancer development. However, it remains unclear what potential mechanisms of HMGB1 facilitate MDSC differentiation. In the ...