叶丽林团队及Rafi Ahmed,Di Yu等研究团队在2016年分别独立发现, 慢性病毒感染中,位于淋巴组织内的耗竭程度较低的CXCR5+TCF-1+ Tim3-CD8+T细胞作为耗竭前体细胞(progenitor exhausted T cell, Tpex),功能性响应PD-1 ICB。Tpex的发现打破了将耗竭T细胞作为“Zombie”细胞的固有印象,并立即成为T细胞耗竭领域的研究热点...
The durability of an antitumor immune response is mediated in part by the persistence of progenitor exhausted CD8+T cells (Tpex). Tpex serve as a resource for replenishing effector T cells and preserve their quantity through self-renewal. However, it is unknown how T cell receptor (TCR) ...
The durability of an antitumor immune response is mediated in part by the persistence of progenitor exhausted CD8+T cells (Tpex). Tpex serve as a resource for replenishing effector T cells and preserve their quantity through self-renewal. However, it is unknown how T cell receptor (TCR) enga...
During chronic viral infection, CD8+T cells develop into three major phenotypically and functionally distinct subsets: Ly108+TCF-1+progenitors, Ly108−CX3CR1−terminally exhausted cells and the recently identified CX3CR1+cytotoxic effector cells. Nevertheless, how CX3CR1+effector cell differentiati...
or 16–11 were used49, see Supplementary Data7for sequences. cDNA from BT827 and BT618 had been exhausted for RNA-seq analysis and was not available to perform qPCR. BT646 contained a complex rearrangement involving multiple breakpoints that linked KIAA1549 to BRAF that was not amenable to ...
heart field to the heart primordium is exhausted around HH18 (Waldo et al.2001) and correlates with cells expressingIsl1(van den Berg and Moorman2009). Recent experiments have demonstrated that the chicken pharyngeal mesoderm also contributes to the pharyngeal muscles (Tirosh-Finkel et al.2006; ...
The use of adult stem cells for myocardial tissue repair might be limited in elderly and sick people because their cells are depleted and exhausted. The pr... J Leor,E Guetta,MS Feinberg,... - 《Stem Cells》 被引量: 167发表: 2010年 CD133+ Cancer Stem-like Cells in Small Cell Lung ...
BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia 2021, Journal of Clinical Investigation Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia 2021, Nature Genetics View all citing ...
Understanding how to prevent T cell exhaustion and thus extend their effector function is currently one of the most pressing questions in immuno-oncology (Mann and Kaech, 2019). Cancer immunotherapies based on reinvigoration of exhausted T cells, such as checkpoint blockade therapies, have provided ...
When conservative forms of therapy are exhausted, patients can elect to have artificial joint replacement surgery to relieve pain and regain some mobility. The question of whether, in the earliest stages of disease, it is possible to stimulate repair in order to spare the joint rests on the ...