progenitor exhausted T cell, Tpex分享到: 耗竭前体细胞分类: 生物学词汇 | 查看相关文献(pubmed) | 免费全文文献 详细解释: 叶丽林团队及Rafi Ahmed,Di Yu等研究团队在2016年分别独立发现, 慢性病毒感染中,位于淋巴组织内的耗竭程度较低的CXCR5+TCF-1+ Tim3-CD8+T细胞作为耗竭前体细胞(progenitor exhausted T...
Here, we perform single-cell RNA -sequencing of tumors from patients with ESCC undergoing neoadjuvant ICB, revealing a subset of exhausted CD8+ T cells expressing SPRY1 (CD8+ Tex-SPRY1) that displays a progenitor exhausted T cell (Tpex) pheno-type and correlates with complete response to ICB...
The use of adult stem cells for myocardial tissue repair might be limited in elderly and sick people because their cells are depleted and exhausted. The pr... J Leor,E Guetta,MS Feinberg,... - 《Stem Cells》 被引量: 167发表: 2010年 CD133+ Cancer Stem-like Cells in Small Cell Lung ...
Understanding how to prevent T cell exhaustion and thus extend their effector function is currently one of the most pressing questions in immuno-oncology (Mann and Kaech, 2019). Cancer immunotherapies based on reinvigoration of exhausted T cells, such as checkpoint blockade therapies, have provided ...
We selected A2B5, a cell-surface marker of glial progenitor cells, as our target for immunolabeling for two reasons. First, A2B5 is known to be enriched in PAs and absent from nonglial cell types23. Second, we found that A2B5 detection was enriched six-fold in murine neural stem cell...
41,42,43,44,45 Since the TLCPlo/int cells also expressed markers such as CXCR5, BCL-6, and TCF-1 and had high expression of co-inhibitory receptors (activated, exhausted-like), we tested whether these cells are the CD4 T cell analogs of the progenitor-like CXCR5+ CD8 T cells. ...
In humans, NPCs are exhausted en masse by 34–36 weeks of gestation, with 60% of nephrons forming during the third trimester31. In mice, nephrogenesis ends by postnatal day 3 (P3)32,33. Historically, the NPC population has been described as a transitory cell population that progresses ...
Isl1 was initially hypothesized to be a specific marker for the SHF and to solely function in the development of SHF lineages. However, accumulating data strongly indicate that Isl1 is already expressed in the common cardiac progenitor cell population and has an important function in heart developm...
[5]. Because of their unexhausted differentiation and proliferation potential, pSMCs are thought to have better therapeutic efficacy compared with mature SMCs [6,7]. Mature SMCs isolated from donor tissues are insufficient in number for transplantation, have limited proliferative potential, and exhibit...
Clonal hematopoiesis (CH) is defined as a single hematopoietic stem/progenitor cell (HSPC) gaining selective advantage over a broader range of HSPCs. When linked to somatic mutations in myeloid malignancy-associated genes, such as TET2-mediated clonal he