During chronic viral infection, CD8+ T cells develop into three major phenotypically and functionally distinct subsets: Ly108+TCF-1+ progenitors, Ly108−CX3CR1− terminally exhausted cells and the recently identified CX3CR1+ cytotoxic effector cells.
PA have been previously reported to exhibit heterogeneity with the presence of immune cells intertwined with cancer cells19,20,22. Indeed, we also found evidence of immune cells within our scRNAseq data (Fig.3a, b). We examined tumor-associated cells for gene signatures of microglia and macroph...
Precursor cells of the heart, however, are located more ventrally and medially to the progenitors of the ASM. Interestingly, this arrangement resembles the relative position of cells of the FHF and SHF lineage in vertebrates, but a contribution of Isl1-positive cells to the tunicate heart could...
The subset of CD4 T cells expressing LAG-3, CXCR5, and PD-1 that we have characterized in this study and named TLCPlo/int cells strikingly resembles a population of CD8 T cells known as the TPEX (T precursor exhausted). These TPEX cells have progenitor-like potential and are characterized...
Smooth muscle progenitor cells (pSMCs) differentiated from human pluripotent stem cells (hPSCs) hold great promise for treating diseases or degenerative conditions involving smooth muscle pathologies. However, the therapeutic potential of pSMCs derived from men and women may be very different. Cell sex...