Apoptotic cells were found in all cases examined, and their frequency increased significantly during acute rejection (0.17 vs. 9.0; P<0.05), The immunoreactivity of Fas and Fast antigen was higher in specimens with acute rejection than in those with stable graft function. Increased a...
gain-of-function ofmiR-277rescues both structurally as well as functionally the Aβ42-mediated neurodegeneration. Furthermore, we identifiedhead involution defective(hid), an evolutionarily conserved proapoptotic gene, as one of the targets
Pro-apoptotic proteins from the reaper, hid, grim (RHG) family are primary regulators of programmed cell death in Drosophila due to their antagonistic effect on inhibitor of apoptosis (IAP) proteins, thereby releasing IAP-inhibition of caspases that effect apoptosis. Using a degenerate PCR approach...
unnecessary apoptosis; Phase 2: in response to continuous and severe DNA damaging stresses when apoptosis is required to discard severely dam- aged cells, TFIIS.h is induced and accumulated by continuously activated p53 to rescue the transcription elonga- tion arrest of apoptotic genes, such as ...
In summary, SIVA is a proapoptotic gene that is expressed in a broad scope of tissues, including cells of the immune system, tumor cells, and in the CNS. SIVA is induced in response to p53 and E2F1, two tumor suppressor genes that function in cell cycle regulation and apoptosis. Up-regu...
Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim. 2000. Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim . Mol. Cell. Biol. 20 :2907–2914 ... Z Song,B Guan,A Bergman,...
Thus, diabetes-enhanced apoptosis represents an important mechanism through which healing is impaired, and this can be explained, in part, by diabetes-increased expression of proapoptotic genes and caspase activity. 展开 关键词: Diabetes DOI: 10.2337/diabetes.55.02.06.db05-1201 ...
Fig. 4: CNOT3 deletion up-regulates pro-apoptotic genes during positive selection. aScatter plot of genes expressed inCnot3f/fandCnot3f/fCd4-Cre thymocytes during positive selection. Red dots indicate significantly up or down-regulated genes (2-fold change, FDR P < 0.05).bGene ontology ...
Transcriptome-wide mRNA expression profiling shows that DOT1L inhibition results in the downregulation of genes involved in cellular biosynthesis pathways and the upregulation of proapoptotic genes. Consistent with the results of transcriptome analysis, the unbiased large-scale metabolomic analysis showed ...
A hallmark of cancer cells is the loss of apoptotic control which allows cells to survive longer and gives more time for the accumulation of mutations which can increase invasiveness during tumor progression, stimulate angiogenesis, deregulate cell proliferation and interfere with differentiation36. More...