Essential role of the iron-sulfur cluster binding domain of the primase regulatory subunit Pri2 in DNA replication initiation. Protein Cell 2015, 6, 194-210.Liu, L., and Huang, M. (2015) Essential role of the i
DNA Repair Enzymes: Cell, Molecular, and Chemical Biology Abstract Primasesplay a crucial role in the initiation ofDNA synthesisduring replication byde novo synthesisof shortRNAor DNA “primers.” In recent years, evidence has accumulated which expands the essential roles ofprimasesto include, not ...
are involved in the initiation phase of SV40DNA replication[6]and we propose that they play a similar role in the DNA synthesome[26]. It was, therefore, proposed thattopoisomerase Iand RPA constitute the “initiation” component of the DNA synthesome. Together, the core and initiation componen...
35K What does primase do in DNA replication? In this lesson, see the primase definition, primase function, primase types, and the role of primase in DNA replication. Related to this QuestionWhat is the function of DNA ligase in DNA replication? What is the function of the DNA polymerase?
PRIM1 mapping at chromosome 12q13 is the smallest subunit within a polymerase α (Pol α) heterotetrameric complex, which plays a crucial role in DNA replication by facilitating catalytic function and synthesizing RNA primers as starting point for the replication of the leading and lagging strand...
Small tandem duplications of DNA occur frequently in the human genome and are implicated in the aetiology of certain human cancers. Recent studies have suggested that DNA double-strand breaks are causal to this mutational class, but the underlying mechan
Initiation of eukaryotic DNA replication is a stringently regulated process that requires the cooperation of many proteins and protein complexes to occur efficiently, at the origins of replication, and once per cell cycle. The initiation of DNA replication requires a protein complex composed of two DN...
Additionally, the CST complex removes G-quadruplex DNA structures that form within G-rich regions of the genome, especially at telomeres16. Still, new functions for the CST complex are being uncovered such as its role in replication stress17. Notably, numerous mutations within the CST complex ...
Single-stranded DNA-binding protein complex from Helicobacter pylori suggests an ssDNA-binding surface. Single-stranded DNA-binding protein (SSB) plays an important role in DNA replication, recombination, and repair. SSB consists of an N-terminal single-stran... KW Chan,YJ Lee,CH Wang,... 被...
DNA polymeraseα-primase (pol-prim) plays a central role in DNA replication in higher eukaryotes, initiating synthesis on both leading and lagging strand single-stranded DNA templates. Pol-prim consists of a primase heterodimer that synthesizes RNA primers, a DNA polymerase that extends them, and...