A role for DNA primase in coupling DNA replication to DNA damage response. EMBO J. 16 : 639-650.Marini F, Pellicioli A, Paciotti V, Lucchini G, Plevani P, Stern D F, Foiani M. A role for DNA primase in coupling DNA replication to DNA damage response. EMBO J. 1997; 16 :639–...
DNA Replication: DNA replication is the process of making two copies of DNA from one parent strand. The process is complex, especially in eukaryotes that store their DNA in the nucleus. Many enzymes are involved in DNA replication, such as DNA polymerase, primase, helicase, topoisomerase and mo...
近日,来自美国洛克菲勒大学的Titia de Lange和Joseph T. P. Yeeles研究团队在Nature上发表题为CST–polymerase α-primase solves a second telomere end-replication problem的文章,发现第二个末端复制问题,在体外重构的DNA复制系统中,后随链DNA复制...
When DNA replication is inhibited during the synthesis (S) phase of the cell cycle, a signaling pathway (checkpoint) is activated that serves to prevent mitosis from initiating before completion of replication. This replication checkpoint acts by down-regulating the activity of the mitotic inducer cd...
During DNA replication in, a switch between DnaG primase and DNA polymerase III holoenzyme (pol III) activities has to occur every time when the synthesis of a new Okazaki fragment starts. As both primase and the 蠂 subunit of pol III interact with the highly conserved C-terminus of single...
In baker׳s yeast, the genes are named pril (small primase subunit), pri2 (large primase subunit), pol2 (subunit B), and poll (DNA polymerase alpha). Mutations within the two primase and single DNA polymerase genes lead to phenotypes consistent with other DNA replication mutants. For ...
Domain mapping of Escherichia coli RecQ defines the roles of conserved N- and C-terminal regions in the RecQ family. RecQ DNA helicases function in DNA replication, recombination and repair. Although the precise cellular roles played by this family of enzymes remain elusi... Douglas,A,Bernstein...
Prior to replication, the DNA double helix must be untwisted by which type of enzyme? (a) Topoisomerase (b) Ligase (c) Polymerase (d) Helicase (e) Primase. DNA Replication: DNA replication occurs in the regions of...
The herpes simplex virus type 1 (HSV-1) UL8 DNA replication protein is a component of a trimeric helicase-primase complex. Sixteen UL8-specific monoclonal ... H.S. Marsden,G.W. McLean,E.C. Barnard,... - 《Journal of Virology》 被引量: 94发表: 1997年 加载更多来源...
DNA-Containing Viruses JAMES H. STRAUSS, ELLEN G. STRAUSS, in Viruses and Human Disease (Second Edition), 2008 DNA Replication Large T antigen binds to specific sites within the Ori to promote replication of the viral genome. Binding first unwinds the DNA. Then T antigen associates with repli...