As both primase and the 蠂 subunit of pol III interact with the highly conserved C-terminus of single-stranded DNA-binding protein (SSB), it had been proposed that the binding of both proteins to SSB is mutually exclusive. Using a replication system containing the origin of replication of ...
Despite extensive studies on DNA replication, the exchange mechanisms of DNA polymerase during replication remain unclear. Existing models propose that this exchange is facilitated by protein partners like helicase. Here we present data, employing a comb
The replication of DNA is a critical step during mitosis so that the daughter cells end up with identical copies of the parent cell's DNA. The process involves the enzyme DNA polymerase, along with multiple other biomolecules, which does the copying of exposed single strand of DNA.Answer and ...
The leading strand is the simplest to replicate. Once the DNA strands have been separated, a short piece of RNA called a primer binds to the 3' end of the strand. The primer always binds as the starting point for replication. Primers are generated by the enzyme DNA primase. Why do Okaz...
In the DNA replication, the unzip (melting of hydrogen bonds) of the double stranded helix of DNA molecule occurs, and this reaction is carried out by... See full answer below.Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our ...
Martinez-Jimenez,I Maria,Calvo,A Patricia,Garcia-Gomez,Sara,Guerra-Gonzalez,Susana,Blanco,Luis 摘要: Human PrimPol is a monomeric enzyme whose DNA primase activity is required to rescue stalled replication forks during nuclear and mitochondrial DNA replication. PrimPol contains an... 查看全部>>...
Antibody diversification is essential for an effective immune response, with somatic hypermutation (SHM) serving as a key molecular process in this adaptation. Activation-induced cytidine deaminase (AID) initiates SHM by inducing DNA lesions, which are ultimately resolved into point mutations, as well ...
Particularly, we demonstrate redundancy of the Pol α-primase DNA polymerase activity in replication and show that Pol α-primase and the lagging-strand Pol δ can be re-used within the replisome to support the synthesis of large numbers of Okazaki fragments. This unexpected malleability of the ...
, primase DnaG (K02316), and single-strand DNA-binding protein (SSB, K03111), with a high relative abundance and involved in bacterial DNA replication, had highest expression levels in BT group. Therefore, it can be concluded that before transport, bacterial reproduction was more active than ...
Where does DNA synthesis happen in eukaryotic cells? What enzyme produces a new DNA strand during DNA replication? What does RNA primase do in DNA replication? Explore our homework questions and answers library Search Browse Browse by subject...