PolI is a well-characterized enzyme involved in DNA replication and repair. During the replication of the lagging strand DNA, it plays a particularly important role in the processing of Okazaki fragment1,2. PolI is composed of a single polypeptide chain consisting of about 930 residues. It ...
For years,primasehas been considered a keyenzymeinDNA replicationbecause it is the only enzyme that can initiate the synthesis of the newDNA strandsde novo. More recent data, however, indicate that this enzyme is also critical for coupling replication and repair, as well as fortelomeremaintenance...
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Although all known cellular replication systems utilize an RNA primer for DNA replication initiation, two structurally distinct and non-homologous versions of primases catalyze primer synthesis. In all bacteria, the primase involved in DNA replication, belongs to the DnaG superfamily and contains a cat...
PolI is a well-characterized enzyme involved in DNA replication and repair. During the replication of the lagging strand DNA, it plays a particularly important role in the processing of Okazaki fragment1,2. PolI is composed of a single polypeptide chain consisting of about 930 residues. It posse...