(1999). The functional role of a DNA primase in chloroplast DNA replication in Chlamydomonas reinhardtii. Arch Biochem Biophys, 369(1), 174-180.Nie Z, Wu M (1999) The functional role of a DNA primase in chlorop
35K What does primase do in DNA replication? In this lesson, see the primase definition, primase function, primase types, and the role of primase in DNA replication. Related to this QuestionWhat is the function of DNA ligase in DNA replication? What is the function of the DNA polymerase?
Primaseis a particularly intriguing chemotherapeutic target due to its essential role inDNA replication, and a number of inhibitors have been synthesized (Fig. 10). Some nucleotide analogues will inhibit different DNA primases. NTP analogues containing arabinofuranosyl sugars (araATP, 2-Fluoro-araATP)...
Transcription-replication conflicts (TRCs), especially Head-On TRCs (HO-TRCs) can introduce R-loops and DNA damage, however, the underlying mechanisms are still largely unclear. We previously identified a chloroplast-localized RNase H1 protein AtRNH1C that can remove R-loops and relax HO-TRCs for...
A plasmid DNA primase active in discontinuous bacterial DNA replication. Nature (London) 290:217-221.Wilkins, B.M. , Boulnois, G.J. & Lanka, E. ( 1981 ) A plasmid DNA primase active in discontinuous bacterial DNA replication . Nature 290 : 217 – 221 ....
PRIM1 mapping at chromosome 12q13 is the smallest subunit within a polymerase α (Pol α) heterotetrameric complex, which plays a crucial role in DNA replication by facilitating catalytic function and synthesizing RNA primers as starting point for the replication of the leading and lagging strand...
Single-stranded DNA-binding protein complex from Helicobacter pylori suggests an ssDNA-binding surface. Single-stranded DNA-binding protein (SSB) plays an important role in DNA replication, recombination, and repair. SSB consists of an N-terminal single-stran... KW Chan,YJ Lee,CH Wang,... 被...
The 48 and 58 kDa primase subunits cooperate in the synthesis of small RNA primers. p48 is the catalytically active subunit (2), while p58 couples p48 to the polymerase to allow the transfer of primers to the active site. The p58 subunit may also play a role in regulation of primer...
DNA Replication: DNA replication occurs in the regions of the nucleus and forms new DNA strands. This process implies the synthesis of DNA from DNA. It requires a range of enzymes, each of which has a significant function. Ans...
DNA primase serves as a key target for regulation of DNA replication initiation, telomere maintenance, and response to DNA damage or fork stalling, in part through its physical interactions with other proteins involved in DNA replication and in checkpoint signaling (19). Primase interacts physically ...