Nuclear factor kappa B (NF- κB) is a nuclear transcriptional activator that plays a central role in the stress response and inflammation, and is activated by pathogenic stimuli.[5] In this study, we examined the therapeutic effects of Dan-shao-hua- xian and the expression of PPAR-γ and ...
Nuclear factor kappa B (NF- κB) is a nuclear transcriptional activator that plays a central role in the stress response and inflammation, and is activated by pathogenic stimuli.[5] In this study, we examined the therapeutic effects of Dan-shao-hua- xian and the expression of PPAR-γ and ...
Conclusions Simvastatin inhibits the cardiac hypertrophy and improves cardiac function. The mechanism of simvastatin on cardiac remodeling and function relates to the increase of PPARγ expression and preventing the NF-κB activation. 展开 关键词: simvastatin rabbit congestive heart failure hypertrophy PPAR...
Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). ...
The present study was designed to investigate the expression changes of PPAR-alpha, -beta, -gamma and NF-kappa B in the hippocampus of rats with global cerebral ischemia/reperfusion injury (GCIRI) after treatment with agonists or antagonists of PPAR-gamma. Methods A rat GCIRI model was ...
15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma15-LIPOXYGENASE-1NF-κBPPAR
IR, insulin resistance; LBD, ligand binding domain; MNT, mannitol; NF-κB, nuclear factor-kappa B; NO, nitric oxide; PBS, phosphate buffered saline; PE, phenylephr- ine; PG, pioglitazone; PPARγ, peroxisome proliferator-activated receptor gamma; PPARγ Low -HUVEC, HUVEC low-PPARγ-expressing...
Tong-xin-luo Capsule inhibits left ventricular remodeling in spontaneously hypertensive rats by enhan- cing PPAR-gamma expression and suppressing NF-kappa B activity [J]. Chin Med J,2008,121(2) : 147- 154.Bu PL, Zhao XQ, Wang LL, Zhao YX, Li CB and Zhang Y (2008). Tong-xin-luo ...
Abbreviations: ERK, extracellular regulated protein kinase; PI3K, phosphatidylinositol 3-kinase; NF-kB, nuclear factor kappa B; NOX, NADPH oxidase; rosi, rosiglitazone; RXR, retinoid X receptor; iNOS, inducible NO synthase; IKK, IkB kinase; HG, high glucose; HF, high fat; PA, palmitic acid;...
The PPAR-γ modulators effect was related mainly to attenuating the Is/R induced changes, namely, apoptosis and nuclear factor-kappa B (NF-κB) expression along with its downstream target genes such as pro-inflammatory cytokines [8]. Moreover, the characters of p38 mitogen-activated protein ...