Nuclear factor kappa B (NF- κB) is a nuclear transcriptional activator that plays a central role in the stress response and inflammation, and is activated by pathogenic stimuli.[5] In this study, we examined the therapeutic effects of Dan-shao-hua- xian and the expression of PPAR-γ and ...
but the sod activity and nf-kappa b expression were weakened in the hippocampus. rosiglitazone treatment significantly protected rats from slm function impairment and neuron death, and resulted in higher expressions of sod activity and nf-kappa b, but lower contents of mda and inflammatory factors....
展开 关键词: activator protein-1 nuclear factor-kappa B troglitazone ciglitazone peroxisome proliferator activated receptor gamma monocyte chemoattractant protein-1 15d-PGJ2 DOI: 10.1046/j.1523-1755.2002.00476.x 被引量: 38 年份: 2002 收藏...
HT Qi,ZH Liu,B Jiang,C Zou,WP Jiang 展开 摘要: Aim To observe the effects of simvastatin on PPARγ and p65 subunit of NF-κB and to invest the mechanism of simvastatin preventing hypertrophy and keeping cardiac function. Methods 24 rabbits were divided into 4 groups. Rabbits received sh...
latedinhibitoryκBkinasealpha/beta(phosphor-IKKα/β)andthecytokinesincludingtumornecrosisfactoralpha(TNFα),interleukin-6(IL-6),solubleintercellularadhesionmolecule-1(sICAM-1)andsolublevascularcellularadhesionmolecule-1(sVCAM-1),suggestingthatTZDsactindeedthroughaPPARγ-dependentNF-κBtrans-repressionpathway....
Although the ability of PPAR-gamma agonists to antagonize inflammatory responses by transrepression of nuclear factor kappa B (NF-kappaB) target genes is linked to antidiabetic and antiatherogenic actions, the mechanisms remain poorly understood. Here we report the identification of a molecular pathway...
Tong-xin-luo capsule inhibits left ventricular remodeling in spontaneously hypertensive rats by enhancing PPAR-gamma expression and suppressing NF-kappa B activity[J].Chinese Medical Journal,2008,(2):147-154.Bu PL, Zhao XQ, Wang LL, Zhao YX, Li CB, Zhang Y. Tong-xin-luo capsule inhibits ...
Sesamol suppresses the inflammatory response by inhibiting NF-kappa B/MAPK activation and upregulating AMP kinase signaling in RAW 264.7 macrophages Sesamol is a lignan isolated from sesame seed oil. Li,Zih-Ying,Fang,... - 《Inflammation Research Official Journal of the European Histamine Research ...
Effects of Dan-shao-hua-xian on expression of PPAR-gamma and NF-kappa B in rat liver fibrosis. Hepatobiliary Pancreat. Dis. Int. 2008; 7: 179-84.Wang HY , Cheng ML ( 2008 ). Effects of Dan-shao-hua-xian on expression of PPAR-gamma and NF-kappa B in rat liver fibrosis . ...
Suppression of NF-kappa B was demonstrated by western blot analysis. Down-regulation of MMP-9, TWIST-1, COX-2, and Bcl-2 and up-regulation of Bax were also observed in gastric cancer cells.Conclusion: These results imply that activation of the PPAR gamma signaling pathway through suppression...