Nuclear factor kappa B (NF- κB) is a nuclear transcriptional activator that plays a central role in the stress response and inflammation, and is activated by pathogenic stimuli.[5] In this study, we examined the therapeutic effects of Dan-shao-hua- xian and the expression of PPAR-γ and ...
Conclusions Simvastatin inhibits the cardiac hypertrophy and improves cardiac function. The mechanism of simvastatin on cardiac remodeling and function relates to the increase of PPARγ expression and preventing the NF-κB activation. 展开 关键词: simvastatin rabbit congestive heart failure hypertrophy PPAR...
Target genes for nuclear factor kappa B (NF-κB) are trans-repressed after the binding of a nuclear co-repressor complex, which keeps NF-κB in a repressed and promoter-bound state [63]. PPAR-γ may also control the immune system by virtue of dendritic cells (DC) and macrophages. ...
Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). ...
The present study was designed to investigate the expression changes of PPAR-alpha, -beta, -gamma and NF-kappa B in the hippocampus of rats with global cerebral ischemia/reperfusion injury (GCIRI) after treatment with agonists or antagonists of PPAR-gamma. Methods A rat GCIRI model was ...
latedinhibitoryκBkinasealpha/beta(phosphor-IKKα/β)andthecytokinesincludingtumornecrosisfactoralpha(TNFα),interleukin-6(IL-6),solubleintercellularadhesionmolecule-1(sICAM-1)andsolublevascularcellularadhesionmolecule-1(sVCAM-1),suggestingthatTZDsactindeedthroughaPPARγ-dependentNF-κBtrans-repressionpathway....
omega 3 Polyunsaturated fatty acids (PUFA) inhibit NF-kappa B activity in LPS-Stimulated proximal tubular cells by PPAR gamma activation. 来自 core.ac.uk 喜欢 0 阅读量: 35 作者:H Li,X Ruan,J Moorhead,S Powis,R Fernando,D Wheeler,Z Varghese ...
展开 关键词: Endothelium, Vascular Cell Line Humans Thiazoles Thiazolidinediones Prostaglandin D2 NF-kappa B Receptors, Cytoplasmic and Nuclear Transcription Factors RNA, Messenger DOI: 10.1016/S0090-6980(01)00155-1 被引量: 131 年份: 2001 收藏 引用 批量引用 报错 分享 全部...
Valproic acid sensitizes pancreatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K/Akt signaling pathway Background Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, is reported to exert anti-tumor effects by upregulating the expression of ...
cardioprotection. The receptors are peroxisome proliferator-activated receptor-γ (PPAR-γ), nuclear factor kappa-B (NF-κB), and phosphoinositide 3-kinase (PI3K/AKT). The interaction of receptor and ligan that has the lowest binding energy of the docking simulation is measured with molecular ...