Nuclear factor kappa B (NF- κB) is a nuclear transcriptional activator that plays a central role in the stress response and inflammation, and is activated by pathogenic stimuli.[5] In this study, we examined the therapeutic effects of Dan-shao-hua- xian and the expression of PPAR-γ and ...
Simvastatin increased the mRNA and protein expression of PPARγ and decreased the ac-tivity and protein expression of p65 (P0.01). Conclusions Simvastatin inhibits the cardiac hypertrophy and improves cardiac function. The mechanism of simvastatin on cardiac remodeling and function relates to the ...
EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism. BACKGROUND: Recent studies have shown that fish oil, containing omega-3 polyunsaturated fatty acids (omega-3 PUFAs) eicosapentaenoic acid (EPA) (C20:5 omeg......
PPAR-gammaGene expressionInflammationBackground and Aims: Omega-3 polyunsaturated fatty acids (PUFAs) are natural peroxisome proliferator-activated receptor gamma (PPAR-gamma) ligands. Activated PPAR-gamma protects the cardiovascular system against atherosclerotic lesion formation and exerts its anti-...
L. Effects of Dan-shao-hua-xian on expression of PPAR-gamma and NF-kappa B in rat liver fibrosis. Hepatobiliary and Pancreatic Diseases International . 2008; 7 (2):179–184.Wang HY, Cheng ML. Effects of Dan-shao-hua-xian on expression of PPAR-gamma and NF-kappa B in rat liver ...
CONCLUSION:Dan-shao-hua-xian capsules enhance the expression of PPAR-γ but decrease that of TNF-α and NF-κB in the liver tissues of CCl4-induced hepatic fibrotic rats. These effects may play a role in its activity in treating hepatic fibrosis.国际肝胆胰疾病杂志(英文版)...
NF-kappa BApo E-/-Terminalia arjuna is a medicinal plant well known as a cardiotonic in Ayurvedic system of medicine. We hypothesized that aqueous stem bark extract of T. arjuna (TAE) may inhibit IL-18-induced atherosclerosis via NF-kappa B/PPAR-gamma-mediated pathway in Apo E-/- mice....
L. Effects of Dan-shao-hua-xian on expression of PPAR-gamma and NF-kappa B in rat liver fibrosis. Hepatobiliary and Pancreatic Diseases International . 2008; 7 (2):179–184.Wang HY, Cheng ML. Effects of Dan-shao-hua-xian on expression of PPAR-gamma and NF-kappa B in rat liver ...
Furthermore, DIA downregulated protein levels as well as mRNA of HMGB-1, TLR4, NF-kappa B p65 expression, and enhanced PPAR-gamma expression. Moreover, DIA ameliorated apoptotic (Bax) and caspase-3 expressions and increased the anti-apoptotic (Bc12) expression. Conclusions This study ...
PPAR-gammaNF-kappa Bp38MAPKBackgroundAcute radiation enteritis (ARE), a common complication of intestinal caused by abdominal and pelvic radiation therapy. Rheinic acid is a major active ingredient derived from Rhubarb. Rhubarb could suppress inflammation, tumor, fibrosis oxidative damage. However, RA...