Wnt/β-catenin通路调节转录辅助因子β-catenin的蛋白水解,由支架蛋白Axin2、GSK3和酪蛋白激酶1组成的β-catenin破坏复合物在没有Wnt的情况下与β-catenin结合。Axin2是一种重要的支架蛋白,它与β-catenin和GSK3直接相互作用,对β-cat...
Abstract:【Abstract】 Objective To explore the role of peroxisome proliferator-activated receptor (PPAR) signaling pathway in the pathogenesis of acne inversa (AI). Methods Skin tissue samples were obtained from 8 AI patients and 4 healthy controls from Hospital of Dermatology, Chinese Academy of Me...
结论 APN可通过上调PPARα/HOXA10通路改善PCOS大鼠子宫内膜容受性,该结果有望为改善PCOS病人妊娠结局的治疗提供实验依据。 关键词:多囊卵巢综合征;脂联素;过氧化物酶体增殖物激活受体α;同源框基因A10;子宫内膜容受性 Abstract:Objective To explore the role of the PPARα/HOXA10 signaling pathway in mediating th...
尿蛋白有显著改善。这些结果证实痹宁汤主要通过PPAR 信号通路在痛风肾疾病中发挥有效作用。结论:本研究初步预测了痹宁汤治疗痛风肾的主要有效成分、潜在靶点、信号通路,为进一步研究痹宁汤对痛风肾的保护机制及临床应用提供新的思路。 关键词 痹宁汤,网络药理学,转录组学,痛风肾 *通讯作者。
篇名: 白术乙醇提取物调节PPAR-γ信号通路促进小胶质细胞摄取及降解Aβ的作用机制研究 TITLE: Study on the promotion effect mechanism of ethanol extract from Atractylodes macrocephala on microglia phagocytosis and degradation of Aβ based on regulating PPAR-γ signaling pathway 摘要: 目的 基于过氧化物酶...
表2分化不同时间PPAR信号通路的差异表达基因变化Table 2Changes of differentially expressed gene in PPAR signaling pathway at different differentiation time 3讨论 脂肪酸是机体主要能量来源之一,通过核受体如PPARs、肝脏X受体及各种转录因...
OBJECTIVE: To investigate the role and mechanism of irisin/peroxisome proliferator-activated receptor alpha (PPAR伪) signaling pathway mediated heme oxygenase-1 in regulating the balance between proliferation and apoptosis of vascular smooth muscle cells. METHODS: FNDC5 overexpression and silencing ...
PPAR-γAP-1信号通路在相关疾病中作用的研究进展 Progress on the Role of the PPAR - γ /AP - 1 Signaling Pathway in Related Diseases 作者: 刘冬梅[1];肖美先[2];王海利[1];赵晓杰[1];韩晓群[3]作者机构: [1]宜春学院化学与生物工程学院,江西宜春336000;[2]宜春市袁州区疾病预防控制中心,江西...
利用转录组学和网络药理学分析研究乙醇紫锥菊通过AMRK和PPAR信号通路对甲状腺功能亢进诱导的氧化应激的改善作用 紫锥菊是一种著名的具有抗氧化特性的植物补充剂。然而,EP对甲状腺功能亢进引起的氧化应激的影响尚…
Exploration on the renal protective effect of Bushen Kaixuan Tongluo Formula on db/db mice based on PPARγ/ERK1/2 signaling pathway WANG You, ZHANG Chengfei, ZHOU Luoqing, JIA Xiaolei, QIN Lingling, WANG Haiyan, WU Lijia, HUANG Yukun, BAO Xincui, YANG Jing, LYU Cuiyan, LIU Tonghua ...