Interestingly, in Group B, several downregulated proteins (FABP1, FABP2, APOC3, HMGCS2, ACADM and PEPCK) were implicated directly in the peroxisome proliferator-activated receptor (PPAR) signaling pathway. Moreover, Group B patients presented a deregulation of some proteins involved in apoptosis/...
PPAR signaling pathway may be an important predictor of breast cancer response to neoadjuvant chemotherapy. PPAR signaling pathway may be an important predictor of breast cancer response to neoadjuvant chemotherapy. Cancer Chemother Pharmacol. 2012;70(5):637-44... YZ Chen,JY Xue,CM Chen,... - ...
PPAR signaling pathway overview Like other nuclear receptor super families, PPAR is essentially a class of ligand-dependent transcriptional regulators, all of which are single subunits with an N-terminal region (A/B region), a highly conserved DNA-binding region (C region), and the hormone ...
在肥胖诱发炎症的过程中,巨噬细胞还可以分泌肿瘤坏死因子(TNF)等促炎症细胞因子。近十年来,涉及 Wnt/β-catenin 信号通路与代谢紊乱之间关系研究迅速发展。Wnt/β-catenin通路调节转录辅助因子β-catenin的蛋白水解,由支架蛋白Axin2、GSK...
与PCOS组比较,各组大鼠妊娠率一致;但PCOS+APN+GW组大鼠胚胎数量相对于PCOS+APN组显著减少且发育迟缓。结论 APN可通过上调PPARα/HOXA10通路改善PCOS大鼠子宫内膜容受性,该结果有望为改善PCOS病人妊娠结局的治疗提供实验依据。 关键词:多囊卵巢综合征;脂联素;过氧化物酶体增殖物激活受体α;同源框基因A10;子宫内膜容...
which is regulated by PPARs and TLR-NF-κB signaling pathway,respectively,has been broken down,resulting in inflammatory cascade and eventually causing chronic non-infectious inflammatory diseases,such as atherosclerosis,ulcerative colitis and rheumatoid arthritis.This review mainly focuses on the ...
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PPAR-gamma signaling pathway in placental development and function: a potential therapeutic target in the treatment of gestational diseases. Theocharis, "PPAR-γ signaling pathway in placental development and function: a potential therapeutic target in the treatment of gestational diseases," Expert... ...
Cytosolic Phospholipase A2α and PPAR-γ Signaling Pathway Counteracts TGF-β-mediated Inhibition of Primary and Transformed Hepatocyte Growth Hepatocellular carcinoma often develops in the setting of abnormal hepatocyte growth associated with chronic hepatitis and liver cirrhosis. Transforming gr... H ...
(PPARγ)caninhibittheinvasionandmetastasisofhepatocellularcarcinoma(HCC)byinhibitingprolifer ationandadhesionofHCCcells,degradationofextracellularmatrixandangiogenesis.Therefore,themecha nismsthatPPARγsignalingpathwayinhibitstheinvasionandmetastasisofHCCmayprovidehelpfortheclini caltreatment,andisexpectedtoimprovethe...