and chemokine-chemokine receptor interaction were significantly enriched in the AI lesions. GSEA demonstrated that the PPAR signaling pathway was significantly weakened in the AI lesions. The mRNA expression levels of PPARA and PPARG were significantly lower in the AI patients (0.336 ± 0.120, 0.253 ...
10. Li Y, Yuan L, Jiang S, Liu S, Xia L, Shen H, et al. Interleukin-35 stimulates tumor necrosis factor-α activated osteoblasts differentiation through Wnt/β-catenin signaling pathway in rheumatoid arthritis. Int ...
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工程技术2区)上发表了题为“Red raspberry extract (Rubus idaeus L shrub) intake ameliorates hyperlipidemia in HFD-induced mice through PPAR signaling pathway”的文章,文章对红树莓提取物(RRE)对高脂血症小鼠降血脂作用及其机制展开了系列研究。
Abstract:Objective To explore the role of the PPARα/HOXA10 signaling pathway in mediating the effect of adiponectin (APN) for improving endometrial receptivity in a rat model of polycystic ovary syndrome (PCOS). Methods Forty female SD rat models with letrozole-induced PCOS were randomized, with...
表2分化不同时间PPAR信号通路的差异表达基因变化Table 2Changes of differentially expressed gene in PPAR signaling pathway at different differentiation time 3讨论 脂肪酸是机体主要能量来源之一,通过核受体如PPARs、肝脏X受体及各种转录因...
痹宁汤基于网络药理学–转录组学分析 通过PPAR 信号通路抑制痛风肾的 作用机制 佟 颖1*,高一然2 1黑龙江中医药大学第一附属医院风湿科,黑龙江 哈尔滨 2黑龙江中医药大学第一临床医学院,黑龙江 哈尔滨 收稿日期:2023年7月18日;录用日期:2023年8月9日;发布日期:2023年8月16日 摘 要 目的:痛风肾是...
参与转录过程的PPAR辅因子的募集由位于E/F结构域的配体依赖性激活功能(AF-2)介导[5]。 图1 PPAR受体结构 03 靶点功能 3.1. 糖脂代谢 PPARα和PPARδ在氧化组织中高度表达,并调节与底物传递、底物氧化和氧化磷酸化(OXPHOS)的相关基因[6]。PPARα主要在肝脏、心脏、骨骼肌、棕色脂肪组织(BAT)、肠道和肾脏中表达...
然而,EP对甲状腺功能亢进引起的氧化应激的影响尚未得到研究。本研究旨在采用转录组学和网络药理学分析相结合的综合策略,评估乙醇紫锥菊(EEP)对甲状腺功能亢进诱导的氧化应激小鼠的抗氧化作用。首先,通过甲状腺素(160 mg/kg)和EEP(1、2或4 g/kg)每天一次诱导甲状腺功能亢进小鼠模型,持续2周。测试了体重、促甲状腺...
This study reviews the research progress of this signaling pathway in thecardiovascular system,renal system,immune system and other systems in order to provide new targets and strate-gies for its treatment.Key words:PPAR -γ;AP -1;signaling pathway;diseases1 转录因子 PPAR -γ 概述过氧化物酶体...