PPAR signaling pathway overview Like other nuclear receptor super families, PPAR is essentially a class of ligand-dependent transcriptional regulators, all of which are single subunits with an N-terminal region (A/B region), a highly conserved DNA-binding region (C region), and the hormone ...
(2008). PPAR-gamma signaling pathway in placental development and function: a potential therapeutic target in the treatment of gestational diseases. Expert opinion on therapeutic targets, Vol. 12, No. 8, pp 1049- 1063.Giaginis C, Spanopoulou E, Theocharis S (2008) PPAR-gamma signaling ...
各差异基因的表达量变化见表2。 表2分化不同时间PPAR信号通路的差异表达基因变化Table 2Changes of differentially expressed gene in PPAR signaling pathway at different differentiation time 3讨论 脂肪酸是机体主要能量来源之一,通过核受...
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The PPAR signaling pathway plays an essential role in trophoblastic cell fusion, migration, angiogenesis, lipid metabolism, and trophoblastic cell cycle progression, and its overactivation suggests complex biological functions, including placental immune tolerance, trophoblastic cell invasion, syncytium ...
PPAR signaling pathway may be an important predictor of breast cancer response to neoadjuvant chemotherapy. PPAR signaling pathway may be an important predictor of breast cancer response to neoadjuvant chemotherapy[J]. Cancer Chemother Pharmacol, 2012, 70(5): ... YZ Chen,JY Xue,CM Chen,... -...
and chemokine-chemokine receptor interaction were significantly enriched in the AI lesions. GSEA demonstrated that the PPAR signaling pathway was significantly weakened in the AI lesions. The mRNA expression levels of PPARA and PPARG were significantly lower in the AI patients (0.336 ± 0.120, 0.253 ...
stress markers. Meanwhile, RT-qPCR and Western Blotting demonstrated that the mechanism of the antioxidant effect of EEP reversed the mRNA expression of EHHADH, HMGCR and SLC27A2 and the protein expression of FABP and HMGCR in AMPK and PPAR signaling pathways. This study integrates transcriptomics ...
2019年,合肥工业大学的Lijun Tu等人,在《Food and Chemical Toxiclolgy》杂志(IF2018=3.977,工程技术2区)上发表了题为“Red raspberry extract (Rubus idaeus L shrub) intake ameliorates hyperlipidemia in HFD-induced mice through PPAR signaling pathway”的文章,文章对红树莓提取物(RRE)对高脂血症小鼠降血脂作...
Recent studies that have supported the continuing physiologic and therapeutic relevance of the PPARγ pathway also provide opportunities to develop newer classes of molecules that reduce or eliminate adverse effects. This review highlights key advances in understanding PPARγ signaling in energy homeostasis...