Biochemistry Relaxin activates PPARgamma through a pathway involving CREB and PGC1alpha UNIVERSITY OF NEBRASKA MEDICAL CENTER Robert G. Bennett SinghSudhirRelaxin is a polypeptide hormone of the insulin superfamily involved in extracellular matrix remodeling. Relaxin signals through the Relaxin Family ...
PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization[J]. Proc Natl Acad Sci U S A,2009,106(52):22504-9. [11] Hevener A L,Olefsky J M,Reichart D,et al. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full ...
STAT5a/PPARgamma pathway regulates involucrin expression in keratinocyte differentiation. Hirakawa S,Tohyama M,Yamauchi T,Takashi K,Kagechika H,and Hashimoto K.STAT5a/PPARgamma Pathway Regulates Involucrin Expression in Keratinocyte Differentiation... X Dai,K Sayama,Y Shirakata,... - 《Journal of In...
As COX-2 is overexpressed in human colon cancer and has been implicated in augmenting invasiveness and tumorigenecity, the ability of PPARgamma activation to decrease COX-2 expression and induce apoptosis suggests that the PPARgamma pathway may be considered as a therapeutic target for colon cancer...
we find that PPARγ pathway is activated in aortic valves fromLdlr−/−andApoe−/−mice and in human aortic valves of pre-calcified state but not in calcified valves. WhenPPARGis knockdown, VECs upregulate pro-inflammatory genes and cell adhesion molecules. While PPARγ inhibition promotes...
24、al.15 deoxy delta12,14 prostaglandin j2 inhibits multiple steps in the nf kappa b signaling pathway j . natl acad sci,2000:97(9):4844 9.15 tureyen k,kapadia r,bowen kk,et al.peroxisomeproliferator activated receptor gamma agonists induce neuroprotection following transient focal ischemia in...
This perspective will highlight three lines of evidence which place PPAR-gamma as a key player in a feed-forward pathway favoring differentiation and energy storage by adipocytes.DOI: 10.1621/nrs.01006 被引量: 67 年份: 2003 收藏 引用 批量引用 报错 分享 ...
The peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of adipogenesis and is medically important for its connections to obesity and the treatment of type II diabetes. Activation of this receptor by certain natural or xenobiotic compounds has been shown to stimulate adipogenes...
study, treatment of HT-29 human colon cancer cells with wortmannin, an inhibitor of PI3-kinase potentiated the cell death induced by troglitazone [22], suggesting that growth inhibitory effects of PPARg ligands are at least in part mediated through repression of the PI3-kinase pathway by PTEN....
抗体名:Anti-PPAR gamma 浓度:1mg/1ml % 靶点:详见说明书 免疫原:KLH conjugated synthetic peptide derived from human PP-2A C-terminus 宿主:详见说明书 应用范围:WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 ...