Biochemistry Relaxin activates PPARgamma through a pathway involving CREB and PGC1alpha UNIVERSITY OF NEBRASKA MEDICAL CENTER Robert G. Bennett SinghSudhirRelaxin is a polypeptide hormone of the insulin superfamily involved in extracellular matrix remodeling. Relaxin signals through the Relaxin Family ...
PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization[J]. Proc Natl Acad Sci U S A,2009,106(52):22504-9. [11] Hevener A L,Olefsky J M,Reichart D,et al. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full ...
STAT5a/PPARgamma pathway regulates involucrin expression in keratinocyte differentiation. Hirakawa S,Tohyama M,Yamauchi T,Takashi K,Kagechika H,and Hashimoto K.STAT5a/PPARgamma Pathway Regulates Involucrin Expression in Keratinocyte Differentiation... X Dai,K Sayama,Y Shirakata,... - 《Journal of In...
A novel PPARgamma agonist monascin's potential application in diabetes prevention In this review, we focus on the chemo-preventive properties of monascin against metabolic syndrome through PPARgamma and Nrf2 pathways.doi:10.1039/c3fo60575bHsu, Wei-HsuanPan, Tzu-MingThe Royal Society of ChemistryFood...
Although functional PPARgamma signaling occurs in this cell line, the major troglitazone-induced acid-base responses appear to be mediated by pathway(s) involving PKC/ERK. 展开 关键词: intracellular pH Na + /H + exchanger Nlabeled glutamine alanine aminotransferase activity protein kinase C/...
As COX-2 is overexpressed in human colon cancer and has been implicated in augmenting invasiveness and tumorigenecity, the ability of PPARgamma activation to decrease COX-2 expression and induce apoptosis suggests that the PPARgamma pathway may be considered as a therapeutic target for colon cancer...
ppary中枢神经系统损伤治疗的新作者:单位:邮编:关键词过氧化物酶增殖物激活受体y;中枢神经系统损伤;神经保护过氧化物酶体增殖物激活受体yppary是一类由配体激活的核转 录因子,为核受体超家族中的成员之一。1990年isseman等首次
study, treatment of HT-29 human colon cancer cells with wortmannin, an inhibitor of PI3-kinase potentiated the cell death induced by troglitazone [22], suggesting that growth inhibitory effects of PPARg ligands are at least in part mediated through repression of the PI3-kinase pathway by PTEN....
抗体名:Anti-PPAR gamma 浓度:1mg/1ml % 靶点:详见说明书 免疫原:KLH conjugated synthetic peptide derived from human PP-2A C-terminus 宿主:详见说明书 应用范围:WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 ...
ligand-induced corepressor-dependent NR repression appears to occur through structurally diverse mechanisms. We report two crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) in an inverse agonist/corepressor-bound transcriptionally repressive conformation. Helix 12 is displaced from...