This pharmaceutical composition is useful as a potassium channel activator.doi:US6353016 B1TANAKA MitsushiTSUDA MasamiNAKAMURA AyatsuguUSUS6353016 * 1999年1月13日 2002年3月5日 Nippon Shinyaku Co., Ltd. Potassium channel activators
钾通道激活剂(Potassium-channel Activators) (例如尼可地尔(Nicorandil)) 他汀类(Statins) (例如辛伐他汀(Simvastatin)) 戒烟 ...www.bupa.com.hk|基于6个网页 例句 释义: 全部,钾通道激活剂 更多例句筛选 1. The Experimental Study on the Effects of Potassium Channel Activators on Triggered Activity 钾通...
Potassium channel activators have the ability to open potassium channels in a variety of cells Since most of their effects are antagonized by antidiabetic sulfonylureas, the ATP-sensitive potassium channel is their likely target. Opening of potassium channels leads to hyperpolarization of the surface me...
Channel nameBlockers (Toxins)Blockers (small molecules)Activators BK (Slo, Slo1, BK channel, maxi K+ channel); high conductance Charybdotoxin, iberiotoxin, paxilline, slotoxin, BmP09 Chinese scorpion toxin Tetraethylammonium (TEA) Intracellular Ca2+, NS1608, NS1619, BMS204352, DHS-1, estradio...
Therefore, it was of interest to study the effects of potassium channel activators, such as nicorandil, pinacidil and lemakalim, on those drug-induced EAD in spontaneously beating guinea-pig Purkinje fibres using the intracellular microelectrode technique.2. Early afterdepolarizations induced by ...
KV7 channel activator; also GABAAmodulator and indirect NMDA antagonist 4305ICA 069673 KV7.2/KV7.3 channel opener 4950ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties 4519ML 213 KV7.2 and KV7.4 channel opener 4777ML 277 Selective KV7.1 (KCNQ1) potassium channel activator; augments ...
View and buy high purity Levcromakalim. Kir6 (KATP) channel opener; active enantiomer of Cromakalim. Cited in 3 publications.
First, we still lack sufficiently selective inhibitors and activators among the KCNQ family members. Although retigabine was approved for the treat- ment of epilepsy and XE991 has been widely used as a phar- macological tool, the selectivity of these drugs are still limited at the subtype ...
Background References N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. Amato et al. ACS Med.Chem.Lett., 2011;2:481 The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential. ...
“Modulate” encompasses both channel openers/activators and channel closers/inactivators. The invention also concerns methods of modulating the KCNQ proteins, specifically methods of opening/activating or closing/inactivating the KCNQ2 and/or KCNQ3 channels. Additionally, the present invention encompasses ...