Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart. Hansen et al. J.Pharmacol.Exp.Ther., 2007;321:996 A dual potassium channel activator improves repolarization reserve and normalizes ventricular action ...
Irvine E,Keblesh J,Liu J, et al.Voltage-gated potassium channel modulation of neurotoxic activity in human im- munodeficiency virus type-1 (HIV-1)-infected macro- phages. J Neuroimmune Pharmacol . 2007Irvine E,Keblesh J,Liu J,et al.Voltage-gated potassium channel modulation of neurotoxic ...
Voltage-gated potassium channel Potassium channel KvAP, structure in a membrane-like environment. Calculated hydrocarbon boundaries of the lipid bilayer are
Similarly to several other voltage-gated channels the G-V curves of the wild-type KV1.3 and KV10.1 channels shifted rightward in response to cholesterol loading (decreased channel activity). KV10.1 demonstrates a pronounced Cole-Moore shift, which manifests as altered current activation k...
These proteins may play a role in maintaining the T lymphocyte in a resting state and may be related to the translation inhibitory factors reported to be present at a higher specific activity in quiescent T lymphocytes than in PHA-activated T cells. The expression of the IL-2 receptor (Tac)...
Our results uncover a novel paradigm: direct neurotransmitter activation of voltage-gated ion channels, enabling chemosensing of the neurotransmitter/metabolite landscape to regulate channel activity and cellular excitability.doi:10.1038/s41467-018-04266-wRían W. Manville...
R. Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol. Brain 139, 2164–2181 (2016). Article PubMed PubMed Central Google Scholar Ghovanloo, M. R., Dib-Hajj, S. D., Goodchild, S. J., Ruben, P. C. & Waxman, S. G. Non-psychotropic...
Lidocaine and several other clinically relevant drugs primarily reduce sodium channel activity by enhancing the “inactivation” process of these channels (Fig. 2). This enhancement of sodium channel inactivation causes the channels to become inactivated at potentials where they would normally be in the...
Potassium (KC) channels are largely responsible for shaping the electrical behavior of cell membranes. KC channel currents set the resting membrane potential, control action potential duration, control the rate of action potential firing, control the spread of excitation and Ca2C influx, and provide ...
Abnormal VGSC activity is central to the pat... Massimo,Mantegazza,and,... - 《Lancet Neurology》 被引量: 430发表: 2010年 Functional expression of voltage-gated sodium channels in primary cultures of human cervical cancer. Several ion channels are upregulated in cancer, actually potassium ...