voltage-gated potassium channelCORAL software has been used to build quantitative structure–activity relationships (QSARs) for the prediction of binding affinities (pEC50, i.e., minus decimal logarithm of the 50% effective concentration) of 35 potent inhibitors towards the voltage-gated potassium ...
Na+–K+–2Cl−Cotransporter (NKCC1) is a protein that aids in the active transport of sodium, potassium, and chloride ions across cell membranes. It has been shown that long-term systemic treatment with aldosterone (ALD) can enhance NKCC1 protein expression and activity in the aging cochlea...
Mutations of positively charged amino acids in the S4 transmembrane segment of a voltage-gated ion channel form ion-conducting pathways through the voltage-sensing domain, named ω-current. Here, we used structure modeling and MD simulations to predict pathogenic ω-currents in CaV1.1 and CaV1.3 ...
L. et al. The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Cell 102, 657–670 (2000). 14. Doyle, D. A. et al. The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 280, 69–77 (1998...
To analyze the current-voltage characteristics, we used the corrected potential drop Δφ’, equal to the measured value of the total potential drop minus the ohmic component [40,41]. The limiting diffusion current density ilim was determined as the point of intersection of the limiting current ...
Through dissection of calcium dynamics and sarcolemmal ion channel activity at the release site level we demonstrate that for alternans brought about by increased pacing rate, there is a synergy between these two mechanisms. The modeling suggests that restitution of the action potential due to ...