The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.BARBEITO LuisPEHAR MarianaCASSINA PatriciaALZARI Pedro M.EP1882697A1 * Jul 24, 2006 Jan 30, 2008 Institut Pasteur Post-translationally modified neurotrophins...
Post-translationally modified neurotrophins 专利名称：Post-translationally modified neurotrophins 发明人：Barbeito, Luis,Pehar, Mariana,Cassina,Patricia,Alzari, Pedro M.申请号：EP06291195.3 申请日：20060724 公开号：EP1882697A1 公开日：20080130 专利内容由知识产权出版社提供 专利附图：摘要：The present ...
In nature, peptides are enzymatically modified to constrain their structure and introduce functional moieties. De novo peptide structures could be built by combining enzymes from different pathways, but determining the rules of their use is difficult. We
Figure 1.The multiple effects of post-translational modifications. The effects of post-translational modifications can be seen on multiple levels. Post-translationally modified peptides become sources of altered self, and when in the context of proteins, can affect the tertiary structure of a protein...
aM-Ras and R-Ras are post translationally modified by geranylgeranyl, not farnesyl, and this may contribute to the weaker interaction with RASSF1A M-Ras and R-Ras are post translationally modified by geranylgeranyl, not farnesyl, and this may contribute to the weaker interaction with RASSF1A[tr...
Several post-translationally modified amino acids in the fragments were also observed, which are described below in Table 6. Table 5. Percent occurrence of crystallin fragments compared the total crystallin species as described in Fractions I to IV. CrystallinsPercent occurrence of fragments of ...
aThe virus particle is composed of at least 34 proteins, many of which are post-translationally modified by cellular and viral enzymes. The lipid envelope contains at least 11 virus-encoded glycoproteins that participate in many aspects of the virus life cycle including attachment and entry,cell-to...
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a major class of natural products with a high degree of structural diversity and a wide variety of bioactivities. Understanding the biosynthetic machinery of these RiPPs will benefit the discovery and development of new molecu...
Low-molecular-weight post-translationally modified microcins. Microcins are a class of ribosomally synthesized antibacterial peptides produced by Enterobacteriaceae and active against closely related bacterial species... K Severinov,E Semenova,A Kazakov,... - 《Molecular Microbiology》 被引量: 161发表...
Rapid flow-based synthesis of post-translationally modified peptides and proteins: a case study on MYC's transactivation domain doi:10.1039/D4SC00481GProtein鈥損rotein interactions of c-Myc (MYC) are often regulated by post-translational modifications (PTMs), such as phosphorylation, and crosstalk...