The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.BARBEITO Luis...
1 Proteins under physiological conditions are posttranslationally modified and participate in a range of tasks such as mediation of protein–protein interactions, turnover of protein and localization, enzyme activity, modulation for various signaling cascades, gene expression regulation, cell division,...
The chemists and biologists of Creative Peptides have extensive experience in synthesizing a variety of post-translationally modified peptides, providing superior post-translationally modified peptides for proteomics and epigenetics, etc. We will make appropriate modifications to the peptide according to ...
Technically, the main challenges to studying post-translationally modified proteins are the development of specific detection and purification methods. Fortunately, these technical obstacles are being overcome with a variety of new ...
Many proteins are posttranslationally modified and it is those modifications and their interplay that often determine the function, interaction, and physio-chemical properties of these proteins. A posttranslational modification (PTM) is the covalent attachment of a chemical group to a protein after pro...
post-translationally modulated should pave the way for developing novel and specific therapeutic strategies to treat various human diseases. Background One well-acknowledged underlying etiology of cancer is a loss in cell proliferation control [1]. Regulation of G1 progression is an important step in...
Having a better understanding of how pRb is post-translationally mod‑ ulated should pave the way for developing novel and specific therapeutic strategies to treat various human diseases. Keywords Retinoblastoma, Phosphorylation, Ubiquitination, SUMOylation, Acetylation, Methylation ...
According to previous research, 70% of the total protein in the human body is post-translationally modified by glycosylation [10], and 1% of the human genome is involved in the synthesis and modification of glycoprotein [11]. Notch plays an important role in the development of animal embryonic...
In a broader context, one could argue that the post-translationally modified state of the protein may contribute to the remarkable diversity of protein aggregate structures derived from the same primary amino acid sequence in patients with various neurodegenerative diseases. In addition to providing ...
aSyn in the blood is posttranslationally modified First, we selected a set of candidate PTMs that could be assessed by immunoblotting analyses - tyrosine (Y) 125 phosphorylation (pY125), Y39 nitration (nY39), lysine (K) glycation (AGE), and SUMOylation (SUMO-1) (Fig.1e). We analysed...