Although it has been known for some time that the N-terminal end of NOS2 suffers a post-translational modification, its exact identification has remained... I Navarro-Lerida,MM Corvi,AA Barrientos,... - 《Journal of Biological Chemistry》 被引量: 72发表: 2004年 Discovery and Confirmation ...
Post-translational modification of type II collagen influences T-cell tolerance to self-type II collagenantigen presentationautoantibodyimmune complexesimmunitysynovitistoleranceT-cell response to type II collagen (CII) is essential in collagen-induced arthritis, a murine model of autoimmune arthritis. ...
regulation of gene expression, and complex pathology. To address these limitations, we optimized a hybrid protocol, ICuRuS, for the isolation of nuclei tagged in specific cell-types and histone post translational modification profiling from the striatum of a single mouse. We combined affinity-based ...
In contrast to plants, mammalian O-glycosylation is a well understood posttranslational modification. Substitutions of serine and threonine residues with sugars such as fucose, galactose and N-acetylglucosamine are common modification on mammalian proteins [12], but the most abundant O-glycans in mammal...
Recently, it was revealed that the catalytic activity of PKM2 can be regulated by its posttranslational modification (PTM). Several PTM types, including phosphorylation, methylation, acetylation, oxidation, hydroxylation, succinylation, and glycylation, have been gradually identified on different amino ...
The major pilin subunit of the T4P bears multiple post-translational modifications. By interfering with different steps of the pilin glycosylation and phosphoform modification pathways, we investigated the effect of pilin post-translational modification on the shape and dynamics of microcolonies formed ...
Neddylation, a type of protein post-translational modification similar to ubiquitination, regulates diverse biological processes by affecting subcellular localization, stability, and function of target proteins.7The role of neddylation in cancer cell biology has been extensively investigated with NAE-specific...
Commons mechanisms of post-transcriptional regulation include direct control of either the activity of AraC/XylS transcription factors by protein ligands, small molecules, or post-translational modification, or transcription factor synthesis. In the latter case, RNA-binding proteins such as Hfq, CsrA/...
Peptide mapping of structural polypeptides suggested that 53, 51, 49, and 46.5K polypeptides shared a common primary amino acid sequence. Post-translational modification may be involved in the generation of structural polypeptides and the maturation of the BmDNV-2 virion. 展开 ...
of the complexities of type I IFN signaling network regulation, it is clear that protein post-translational modifications, such as (de-)phosphorylation, ubiquitination, SUMOylation, and acetylation, can be key players14. For example, IFNAR1 can be phosphorylated on a degron motif, leading to ...