Protein Processing, Post-TranslationalPosttranslational modifications diversify the limited amino acid pool, expanding 20 amino acids into a possibly limitless number of residues. These modifications are catalyzed by a large family of proteins specific to each modification. This chapter focuses on the ...
Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities. Oncogene. 2006;25:3006–22. Article CAS PubMed Google Scholar Taira N, Nihira K, Yamaguchi T, Miki Y, Yoshida K. DYRK2 is targeted to the nucleus and...
Post-translational modification is the last step in protein functional realization. Post-translational modification is a key mechanism to increase proteome diversity. Post-translational modification is important for the study of cardiovascular diseases. Open Questions What are the types of post-translational...
modification of proteins such as phosphorylation,ubiquitination,methylation,acetylation(classical modification), andglycation, malonylation,succinylation(nonclassical modification) can rapidly regulate various life activities in cells and expand the diversity of protein functions by affecting the activity, stab...
The target protein of PTMs can be classified into two categories, histones and non-histones. Histone modifications, especially the modifications that take place in H3 and H4, regulate the structure of chromatin to promote transcriptional activation by relaxing chromatin and induce transcriptional repressi...
post-transcriptional modification名词解释1.转录2.不对称转录3.模板链4.编码链5.启动子6.断裂基因7.外显子8.内含子9.剪接体1
Post-translational modification can occur at any step in the "life cycle" of a protein. For example, many proteins are modified shortly after translation is completed to mediate proper protein folding or stability or to direct th...
The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour suppression. It is frequently inactivated in various tumours. The functions of pRb are tightly regulated, where p
Of or relating to a substance or process, such as the addition of sugar groups to form a glycoprotein, that occurs or is formed after translation of protein:a posttranslational modification. American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mi...
Most post-translational protein modifications occur in a relatively low number of bacterial proteins in comparison with eukaryotic proteins, and most of the modified proteins carry low, substoichiometric levels of modification; therefore, their structural and functional analysis is particularly challenging. ...