doi:10.1007/978-1-4614-5891-3_11Timothy Pearman Ph.D.Springer New YorkPearman T. Psychological implications of testing positive for the BRCA gene. In: Hansen NM, editor. Management of the patient at high risk for breast cancer. New York: Springer Science & Business Media; 2013. p. 155-...
and though she contacted the company she trusts most,Myriad Oncology, personally and put a rush on it, it wasn’t until two weeks later I found out I had tested positive for the BRCA1 gene mutation.
Presents an abstract for the article on the discrimination of mutation-positive BRCA1 and BRCA2 from sporadic breast cancer patient tumor biopsies using cDNA microarray analysis.doi:10.1038/14298David J. DugganIngrid A. HedenfalkYidong Chen
With the introduction of targeted treatments specific for tumors with a nonfunctioning BRCA1 or BRCA2 gene, the question whether the BRCA genes are impaired in the tumor is highly relevant. Therefore, we performed genomic profiling of BRCA1-mutated ER+ tumors.Experimental Design: Genomic profiling...
The pCR (pathological complete response) rate for TOP2A-positive (17%) was significantly ( P < 0.005) higher than for TOP2A-negative (2%), while the pCR rate for BRCA1-negative (11%) was non-significantly higher than for BRCA1-positive (5%). The pCR rate of TOP2A-positive and BRCA1-...
However, it has been found that germline BRCA2-mutated BC are often associated with copy number loss of the Rb1 gene, leading to CDK4/6 inhibitors resistance [12]. Therefore, the optimal therapy strategy for ER-positive, BRCA2-mutated BC is currently unclear. In addition, the BRCA2 ...
important genes (BRCA1 and BRCA2)andbreast cancer,presented the newest research resultsfromherlaboratory at the University of Washington in the U.S. and announcedherplanto conduct a large scale collaborative research projectforbreast cancerinHong Kong ...
BRCA1 regulation of epidermal growth factor receptor (EGFR) expression in human breast cancer cells involves microRNA-146a and is critical for its tumor suppressor function Breast cancer 1 (BRCA1)-associated breast cancers are mostly basal-like high-grade ductal carcinomas that frequently overexpress...
Poly (ADP-ribose) polymerase (PARP) inhibitors can be used for patients with castration-resistant prostate cancer who are positive for BRCA gene mutations... K Yoshida - 《Tokyo Womens Medical University Journal》 被引量: 0发表: 2023年 加载更多来源...
We applied a measure of positive selection, based on the likelihood ratio test (LRT) for the presence of sites under positive selection. We considered a significant LRT to be an indicator of a gene being under positive selection. The number of positively selected sites in each gene sequence ...