Grounded theory was used to examine the phenomenon of adults choosing to have predictive genetic testing for HBOC. A sample of 19 women, ten ≤ 35 years old was recruited through community and internet support group announcements. Semi-structured interviews were conducted in-person, by telephone ...
and though she contacted the company she trusts most,Myriad Oncology, personally and put a rush on it, it wasn’t until two weeks later I found out I had tested positive for the BRCA1 gene mutation.
Scott Dudelson/Getty Country singer Morgan Wade says she is having a double mastectomy after testing positive for the gene that comes with a high risk of breast cancer. “I’m feeling fine, I’m just pissed I won’t be able to work out because I really like working out,” th...
Presents an abstract for the article on the discrimination of mutation-positive BRCA1 and BRCA2 from sporadic breast cancer patient tumor biopsies using cDNA microarray analysis.doi:10.1038/14298David J. DugganIngrid A. HedenfalkYidong Chen
However, it has been found that germline BRCA2-mutated BC are often associated with copy number loss of the Rb1 gene, leading to CDK4/6 inhibitors resistance [12]. Therefore, the optimal therapy strategy for ER-positive, BRCA2-mutated BC is currently unclear. In addition, the BRCA2 ...
For example, SOCS3 is an important downstream target gene of JAK/STAT3, and it inhibits JAK1, JAK2, and TYK2, which are important for the proteasome degradation of the gp130 receptor complex, thereby participating in the negative feedback regulation of the STAT3 signal in the normal steady ...
Summary: Therefore, we investigated various biomarkers in breast cancer such as Her2 mutations, Her2 heterogeneity, HR, PIK3CA, PTEN, programmed death receptor ligand 1 (PD-L1), tumor-infiltrating lymphocytes (TIL), micro RNA (miRNA), and BRCA mutations with regard to their clinical impact in ...
Out of all 41samples analyzed for BRCA1 and BRCA2 five were found with 950_951 insA(Asn319fs) at Chr13:32906565 position and one sample with 1032_1033 insA(Asn346fs) at Chr13:32906647, both being frame-shift mutations in BRCA2 gene. 950_951 insA(Asn319fs) mutation is reported as ...
Research into the genomic lineage heterogeneity of HER2-positive breast cancer indicates that genes such asTP53,CDK12,PIK3CA, andRARA, demonstrate high mutation frequencies, in addition to theERBB2gene, pivotal for comprehending the underlying molecular mechanisms of this disease. Comparative analyses bet...
Cytokeratin 5/14-positive breast cancer: true basal phenotype confined to BRCA1 tumors. Mod Pathol 2005.Cytokeratin5/14-positive breast cancer: true basal phenotype confined to BRCA1tumors. Laakso M,Loman N,Borg A, et al. ModPathol . 2005...