Timothy Pearman Ph.D.Springer New YorkPearman T. Psychological implications of testing positive for the BRCA gene. In: Hansen NM, editor. Management of the patient at high risk for breast cancer. New York: Springer Science & Business Media; 2013. p. 155-60....
Beth Dupree, tested me for a BRCA gene mutation that first day we met, and though she contacted the company she trusts most, Myriad Oncology, personally and put a rush on it, it wasn’t until two weeks later I found out I had tested positive for the BRCA1 gene mutation. In fact,...
Little is known about how the breast cancer (BRCA) gene mutation affects women’s decision-making processes. I use a feminist standpoint lens to explore the process by which BRCA-positive women came to socially construct and understand their risk for developing breast and/or ovarian cancer and ...
However, it has been found that germline BRCA2-mutated BC are often associated with copy number loss of the Rb1 gene, leading to CDK4/6 inhibitors resistance [12]. Therefore, the optimal therapy strategy for ER-positive, BRCA2-mutated BC is currently unclear. In addition, the BRCA2 ...
Alpelisib(Piqray) is a P13K inhibitor in pill form that can be used with fulvestrant in women with advanced HR+, HER2-negative breast cancer with a PIK3CA gene mutation. Sacituzumab govitecan(Trodelvy) is a monoclonal antibody with an attached chemotherapy drug. It is used to treat some adva...
According to LC–MS/MS quantification and miRNA analysis of breast cancer drug-resistant cell lines, STAT3 is also an important drug-resistance marker gene [121]. Radiotherapy, as one of the important methods for treating HER2-positive breast cancer in the clinic, has been proven to have a ...
and BRCA2)andbreast cancer,presented the newest research resultsfromherlaboratory at the University of Washington in the U.S. and announcedherplanto conduct a large scale collaborative research projectforbreast cancerinHong Kong and China.
(HER2low) BC that is responsive to novel HER2-targeted ADCs17. HER2lowis defined as HER2 IHC 1+ by itself or 2+ in the absence ofHER2gene amplification by ISH (in situ hybridization). The cut-off for the level of HER2 expression by IHC is only a crude estimation of those who may ...
It is recognized that the majority of BC diagnosed in BRCA1 mutation carriers are triple negative, whereas BRCA2 mutations are frequently associated with HR+/HER2- BC [74], [75]. However, a small proportion of BRCA-associated BC are HER2-positive: 10% for BRCA1-associated BC and 13% for...
PC4 is required for Gene Conversion. Fluctuation analysis of sIgM reversion assay in GC-active subclones. Cells were sorted for IgM(−) in the DT40 Cl18 (WT) and DT40 ΔPC4 clones and for IgM(−)/GFP(+) in the DT40 haPC4oe, DT40 ΔPC4reconand DT40 PC4oeclones. Following a ...