Timothy Pearman Ph.D.Springer New YorkPearman T. Psychological implications of testing positive for the BRCA gene. In: Hansen NM, editor. Management of the patient at high risk for breast cancer. New York: Springer Science & Business Media; 2013. p. 155-60....
In 2008, an estimated 21,650 women were diag- nosed with ovarian cancer.1 Approximately 8% to 15% of these ovarian cancers are attributable to a hereditary predisposition to breast and ovarian cancer caused by germ line mutation of the BRCA1 or BRCA2 gene.2–4 In addition, a small ...
Of women who were conversation initiators, 62% an- swered less than half the true/false BRCA questions correctly. Of women who spoke with relatives specifically about seeking BRCA testing, 12% incorrectly thought they must have an al- tered gene because they already had breast cancer and 49%...
Patients with a higher likelihood to develop BRCA 1 or BRCA 2 mutations are slipping through the cracks, making testing for these mutations a vital part of any breast cancer treatment plan. It’s important for their providers to test for BRCA1 and BRCA2 gene mutations in patients with...
Often,BRCAgene mutation testing is discussed after someone has been diagnosed with cancer. If a mutation is found in the cancer patient, other family members can be tested for that particular gene mutation. The patient’s parents, children, brothers, and sisters all have a 50% chance of havin...
Of the 64 PARP inhibitor candidates with TNBC, 12 (18.8%) tested positive for a BRCA1/2 GPV, whereas of 37 PARP inhibitor candidates with ER-positive, ERBB2-negative breast cancer, 1 (2.7%) tested positive for a BRCA1 GPV, and none were positive for BRCA2. Thus, in the...
Moreover, the causal role of a specific gene is typically less direct than in CF. Suppose a woman from the general population, who is not otherwise at risk for breast cancer, tests positive for theBRCA1gene. She is likely to be told that she has an 85% lifetime risk of developing bre...
As a part of our initial study of BC genetic testing in Trinidad and Tobago, all participants received pre-test counseling including three-generation pedigree and genetic testing for BRCA1/2, PALB2, and RAD51C. The study was approved ...
METHODS: In a randomized controlled trial of BRCA1/2 gene-mutation testing in the Ashkenazi Jewish (AJ) population, we compared testing all participants in the population screening (PS) arm with testing those fulfilling standard FH-based clinical criteria (FH arm). Following a targeted community ...
Figure 2. Clinical Summary: Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer View LargeDownload BRCA indicates breast cancer susceptibility gene; USPSTF, US Preventive Services Task Force. Table 1. Ontario Family History Assessment Toola View LargeDownload Table 2. Manch...