Though my incredible breast surgeon,Dr. Beth Dupree, tested me for a BRCA gene mutation that first day we met, and though she contacted the company she trusts most,Myriad Oncology, personally and put a rush on it, it wasn’t until two weeks later I found out I had tested positive for ...
Experiences of BRCA1/2 Gene Mutation-Positive Women With Cancer in Communicating Genetic Risk to Their RelativesBRCACancerExperiencesFamilyGeneticRisk communicationBackgroundSeven, MemnunShah, Lisa L.Daack-Hirsch, SandraYazici, HulyaUniv Massachusetts Coll Nursing 230 Skinner Hall 651 N Pleasant St ...
[36] Litton JK, Beck JT, Jones JM, et al. Neoadjuvant talazoparib in patients with germline BRCA1/2 (gBRCA1/2) mutation-positive, early HER2-negative breast cancer (BC): Results of a phase 2 study[J]. J C...
Purpose: As estrogen receptor–positive (ER+) breast cancer in BRCA1 mutation carriers arises at an older age with less aggressive tumor characteristics than ER-negative (ER) BRCA1-mutated breast cancer, it has been suggested that these tumors are "sporadic" and not BRCA1 driven. With the in...
A: Comparison of 5-year survival rates between HER2-negative and HER2-positive breast cancer tissues;B: Comparison of 5-year survival rates between BRCA1-negative and BRCA1-positive breast cancer patients 3 讨论 HER2是胃癌和...
Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients. Breast Cancer Res Treat, 115, 359-63.Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients[J] . T. Byrski,T. Huzarski,R. Dent,J. Gronwald,D. Zuziak,C. Cybulski,J. ...
In conclusion, results of the present study demonstrate that positive BRCA1 founder mutation status in TNBC, with no evidence of ovarian or other cancer type in advanced stage, significantly improves prognosis. 展开 关键词: BRCA1 mutation breast cancer triple-negative breast cancer ...
Somasundaram K. Breast cancer gene 1 (BRCA1): role in cell cycle regulation and DNA repair-perhaps through transcription. J Cell Biochem. 2003;88(6):1084-1091. Shiozaki EN, Gu L, Yan N, et al. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for ...
,... - 《Mutation Research/fundamental & Molecular Mechanisms of Mutagenesis》 被引量: 105发表: 2005年 Analysis of BRCA1 and BRCA2 mutations in Brazilian breast cancer patients with positive family history BRCA1 and BRCA2 are the two principal hereditary breast cancer susceptibility genes, and ...
In addition, we show that the predictive power of the BOADICEA risk-prediction model and the Manchester Scoring System was significantly better for BRCA1 than BRCA2, but that the overall sensitivity, specificity and positive-predictive value was lower in this population than has been previously ...