Germline BRCA1 and HMLH1 mutations in a family with male and female breast carcinoma Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease, predisposing to the development of colorectal cancer and other tumor t... ke Borg,J Isola,J Chen,... - 《International Journ...
International Journal of Cancer 81(5): 839-843 1999 ISSN/ISBN:0020-7136 10328242 10.1002/(sici)1097-0215(19990531)81:5<839::aid-ijc28>3.0.co;2-v 003367405 Article emailed within 0-6 h Payments are secure & encrypted Abstract
We addressed these observations in two settings: offspring of 283 mutation carriers and 471 mutation negative subjects from BRCA1/2 mutation-positive families with multiple cases of breast and ovarian cancer (NCI families); and relatives of 115 BRCA1/2 mutation carriers from the Washington Ashkenazi...
Research evaluating the distribution and prevalence of BRCA1/2 mutations in Central and South American populations has been quite limited as compared to the number of studies in North America, Europe, Australia and Israel. Moreover, some of the studies performed in Latin America have analyzed hered...
D. et al. Disruption of the expected positive correlation between breast tumor size and lymph node status in BRCA1-related breast carcinoma. Cancer 98, 1569–1577 (2003). PubMed Google Scholar Goffin, J. R. et al. Impact of germline BRCA1 mutations and overexpression of p53 on prognosis...
We have identified hMLH1 mutations in 2 Amsterdam‐criteria HNPCC families where both male and female gene carriers were affected with breast cancer. To investigate whether these breast cancers were caused by other genetic factors, we analyzed the 2 breast cancer susceptibility genes BRCA1 and BRCA...
模型构建代码主体如下:“glm(Recurrence ~ Age_at_surgery+Menopause+Grade+Size_cm+LN_positive+Chemotherapy+Surgery+mRNA_Subtype+Radiotherapy” ⑵在BRCA1/2胚系突变患者中,通过多元logistic回归分析评估以下因素是否影响第二原发肿瘤的发生:...
A test for trend was performed using Cox regression by including a continuous variable in the model representing the number of breast or ovarian cancers in female first- or second-degree relatives (taking values of 0, 1, 2, 3, etc). Separate variables were derived for the number of breast...
The strongest known risk factor for ovarian cancer is a family history of breast/ovarian cancer; mutations in either the BRCA1 or BRCA2 gene are estimated to account for 10% of the EOC cases [3., 4., 5., 6., 7.]. Female carriers with a BRCA1 mutation have an 18%–54% ...
that these four patients have a high probability of bearing a mutation at a general autosomal dominant breast cancer susceptibility locus that is, 48 – 89% depending on the case, and according to the Claus model modified by Easton.15 However, all belong to female breast cancer-only families....