Though my incredible breast surgeon,Dr. Beth Dupree, tested me for a BRCA gene mutation that first day we met, and though she contacted the company she trusts most,Myriad Oncology, personally and put a rush on it, it wasn’t until two weeks later I found out I had tested positive for ...
Somasundaram K. Breast cancer gene 1 (BRCA1): role in cell cycle regulation and DNA repair-perhaps through transcription. J Cell Biochem. 2003;88(6):1084-1091. Shiozaki EN, Gu L, Yan N, et al. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for s...
6.Schayek H, Haugk K, Sun S, True LD, Plymate SR, Werner H. Tumor Suppressor BRCA1 is Expressed in Prostate Cancer and Control IGF1-R Gene Transcription in an Androgen Receptor-Dependent Manner. Clin Cancer Res (2009) 15:1558–65. doi: 10.1158/1078-...
Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients.BACKGROUND: Ten patients with breast cancer and a breast cancer susceptibility gene 1 (BRCA1) mutation, who presented with stages I to III breast cancer between December 2006 and 2007, were treated with four ...
BRCA1BackgroundTen patients with breast cancer and a breast cancer susceptibility gene 1 (BRCA1) mutation, who presented with stages I to III breast cancer between December 2006 and 2007, were treated with four cycles of neoadjuvant cisplatin, followed by mastectomy and conventional chemotherapy....
NBR1 (neighbor of BRCA1 gene 1) is a protein commonly found in ubiquitin-positive inclusions in neurodegenerative diseases. Due to its high architectural s... E Walinda,D Morimoto,K Sugase,... - 《Journal of Biological Chemistry》 被引量: 46发表: 2014年 Expression profiles and intergenic ...
cell lines tested by protein immunoblotting.D:In vitrocell clonogenecity tested by soft agar assay (anchorage independent assay), ovarian cancer cell line HEY was used as a positive control.E:In vitrotumorigenicity t...
BRCA亚组分析显示:对于BRCA1患者,激素受体状态对预后影响较小;对于BRCA2患者,HR+患者在前5年内预后更好,之后BCSS方面预后较差,5年后的aHR为2.23。 肿瘤亚型分析结果 在符合本次分析条件的4363名BRCA年轻患者中,612名(14.0%)为管腔A型,1038名(23.8%)管腔B型,2373名(54.4%)为三阴型(TNBC),340名(7.8%)为HER2...
[36]. According to this algorithm, splice variants at the position +/− 1 and +/− 2 are classified as likely pathogenic if the variant disrupts the function of the gene product unless the population frequency of the variant is not compatible for a pathogenic variant (minor allele ...
Complicating factors such as the possibility of dealing with more than one mutation within one kindred, skipped generations (as daughters of healthy elderly women in these families, are not offered follow-up, having a low probability of being gene carriers), need to be considered. We present a...