Intronic polyadenylation signal sequences and alternate splicing generate human soluble Flt1 variants and regulate the abundance of soluble Flt1 in the placenta. FASEB J 2007; 21: 3885-3895.Thomas CP , Andrews JI , Liu KZ ( 2007 ) Intronic polyadenylation signal sequences and alternate splicing ...
Polyadenylation signal,that is PolyA signal,is needed for most eukaryotic mRNAs to form their 3’ends and AAUAAA (AATAAA for genomic sequence) is its main form. 多腺苷化信号又称PolyA信号(Polyadenylation signal),AAUAAA(在基因组序列中表示为AATAAA)是其主要形式,参与真核mRNA 3’端形成的重要过程。
1. Initial Transcription 5' ...AAUAAA... 3' The process begins with recognition of the polyadenylation signal sequence (AAUAAA) near the 3' end of the pre-mRNA. 2. Cleavage 5' ...AAUAAAâ–¼... 3' The pre-mRNA is cleaved at a specific site, typically 10-30 nucleotides downstrea...
1) Polyadenylation signal 多聚腺苷酸化信号 1. Polyadenylation signal- deficient retroviruses transformation of human gastric epithelial GES-1 cells; 目的通过人工改变多聚腺苷酸化信号的重组逆转录病毒感染人胃上皮细胞GES-1, 检测病毒转录能否产生病毒-宿主融合转录产物及其是否具有转化胃上皮细胞GES-1的能力。
This processing is directed by distinct polyadenylation signal sequences present in the substrate RNAs. These signals are recognized by an apparatus with conservation of components amongst eukaryotes. This apparatus consists of a complex of factors that control the action of poly(A) polymerases, ...
The major polyadenylation signal (PAS) represents a nucleotide hexamer that adheres to the AATAAA consensus sequence. Over a half of human genes have multiple cleavage and polyadenylation sites, resulting in a great diversity of transcripts differing in function, stability, and translational activity. ...
A novel polyadenylation signal mutation in the α2-globin gene causing α-thalassemia Summary. In a family of Indian origin we have identified a deletion of two bases at the polyadenylation signal sequence of the α 2 -globin gene (AATAAA AA... CL Harteveld,M Losekoot,H.L. Haak,... ...
We conclude that the sequences required for efficient cleavage/polyadenylation of the SV40 early pre-mRNA also constitute an important element of an RNA polymerase II termination signal. A model proposing a mechanism by which the act of pre-mRNA 3' end formation is signaled to the elongating ...
1多腺苷酸化作用(polyadenylation)hnRNA與mRNA所專有的共通特性(rRNA,tRNA,snRNAs都不具有):尾部的多腺苷酸poly(A),ㄧ長串的AMP殘基。poly(A)的..
Also, the sequence rather than the distance between the stop codon and the AAUAAA signal region was critical for gene expression. Transgenic tobaccos with these constructs were also generated, and the position of the polyadenosine tail formation in this region was mapped. Results ...