PML::RARA fusion gene probe fluorescence in situ hybridization showed positive for partial deletion of RARA gene locus and negative for fusion of PML::RARA gene locus. Blood tumor panoramic gene variation test showed STAT3::RARA fusion gene was positive, and no gene variation associated with ...
The PML-RARA fusion is not detectable in historical blood samples of acute promyelocytic leukaemia patientsAnnals of Hematology -doi:10.1007/s00277-021-04472-5William G. DunnMuxin S. GuMargarete A. FabreJonathan CooperGeorge S. VassiliouAnnals of Hematology...
德国QIAGEN,货号:672113,ipsogen PML-RARA bcr1 Kit (24) 价格电议 起批量≥1 盒 最小起订1盒 供货总量66盒 发货地址广东省深圳市 建议售价￥0/盒 更新日期2025年04月11日 即时洽谈立即询价查看联系方式 收藏产品发送留言 VIP9年 深圳子科生物科技有限公司 ...
Total white blood cells (WBC) were obtained by NH4Cl lysis of the erythrocytes. PB mononuclear cells (PBMC) were obtained by ficoll separation. To mimic leukemic samples with varying tumor loads, cells of the PML–RARA expressing cell line NB4 were mixed at different concen- trations in ...
from the blood to the brain. As a consequence, PML loss has an impact on tissue development and maintenance of stem cell pools. In addition, new data suggest that PML regulates self-renewal in cancer stem cells. Finally, the oncogenic fusion protein PML/RARα, contrary to the conventional ...
酸受体RARa基.N融合,分别形成PML.RAR(x和PLZF,RAR旺融合基 因…。PML基因编码环指家族的蛋白成员,它调节造血细胞的分化、 控制细胞的生长和肿瘤发生f21。PLZF基因是具有锌指结构的转录抑 制因子,主要在造血细胞系中的粒细胞系中编码表达。同时在卵巢、
In this respect, it would be interesting to test whether PML loss could influence p21 expression/activity and vice versa. A previous report has shown that p21 expression is diminished in PML-deficient cells.29 So, it would be important to test whether PML contributes to PML/RARa-triggered ...
Student's t-test. N.S.: not significant. 3.2. PCGF2 knockdown induces PML-RARA protein degradation As PCGF2 protein was reduced by ATO treatment, we next tested if suppression of PCGF2 alone could affect PML-RARA gene expression. NB4 cells were lentivirally transduced with non-target ...
7.Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia.[J].A;Melnick;J D;Licht,Blood.1999,第10期 8.FISH detection of PML-RARA fusion in ins(15; 17) acute promyelocytic leukaemia depends on probe size.[J].Lynda...
Ribozymes may also be systemically administered. Systemic absorption refers to the accumulation of drugs in the blood stream followed by distribution throughout the entire body. Administration routes which lead to systemic absorption include: intravenous, subcutaneous, intraperitoneal, intranasal, intrathecal...