Patients with progressive multifocal leukoencephalopathy (PML), which is caused by the JC virus, can be successfully treated using cryopreserved BK-virus-specific T cells, new research suggests. Investigators treated three patients with PML using an infusion of ex vivo–expanded, partially HLA-matched...
It is intended to provide an effective method of treatment of PML (human progressive multifocal leukoencephalopathy). Inhibition of JC virus proliferation in JC virus-infected cells by suppression of JC virus agnogene; and a method of inhibition of the canceration of JC virus-infected cells.Kazuo...
Progressive Multifocal Leukoencephalopathy Diagnosis and Treatment Options PML is diagnosed by testing for the JC virus in cerebrospinal fluid or in a brain biopsy specimen. An MRI can also detect damage caused by PML in the brain. Other possible tests include Cytology exam of the urine, CT scan,...
Update on PML: Lessons from the HIV uninfected and new insights in pathogenesis and treatment 来自 NCBI 喜欢 0 阅读量: 50 作者:EA Hartman,DR Huang 摘要: Significant advances in our understanding of progressive multifocal leukoencephalopathy (PML) and its causative agent, JC virus, have been ...
TCR bias and HLA cross-restriction are strategies of human brain-infiltrating JC virus-specific CD4+ T cells during viral infection Virus-specific CD4(+) T cells play a central role in control of viral pathogens including JC polyoma virus (JCV) infection. JCV is a ubiquitous small DNA v.....
The invention relates to compositions, methods, and kits for treating subjects infected by or at risk of infection with a DNA virus (e.g., a JC Virus or a BK virus). Aspects of the invention are usefu
Adoptive Transfer of JC Virus-Specific T Lymphocytes for the Treatment of Progressive Multifocal Leukoencephalopathy. Ann Neurol. 2021;89(4):769–79. https://doi.org/10.1002/ana.26020. Article PubMed PubMed Central CAS Google Scholar Tan K, Roda R, Ostrow L, McArthur J, Nath A. PML-...
Background PML is a demyelinating disease caused by JC virus (JCV) reactivation in advanced HIV persons. No specific treatment has demonstrated efficacy in improving outcomes. Recent findings showed conflicting evidence on the response of PML lesions after treatment with checkpoint inhibitors, including ...
Objective The increased risk of progressive multifocal leukoencephalopathy (PML) with natalizumab treatment is associated with the presence of anti–JC virus (JCV) antibodies. We analyzed whether anti-JCV antibody levels, measured as ind... T Plavina,M Subramanyam,G Bloomgren,... - 《Annals of ...
Focuses on the biology of JC virus and progressive multifocal leukoencephalopathy. Complex gene regulation of JCV. DB Clifford,EO Major - 《Journal of Neurovirology》 被引量: 7发表: 2001年 Hepatitis B virus-induced CD4 lymphocytopenia: A rare cause of progressive multifocal leukoencephalopathy Progress...