The causative JC virus was isolated from autopsied human brains in 1971. Investigators subsequently focused on its neurotropism and oncogenicity. The pathology of this virus-induced demyelinating disease is better understood now, including the intranuclear target for JC virus infection, promyelocytic ...
Progressive Multifocal Leukoencephalopathy (PML) is a serious, rare and fatal viral disease involving inflammation of the white matter of the brain. PML is caused by the JC virus (JCV). This virus is found in a lot of people, but usually does not cause symptoms. However, it triggers PML ...
进行性多灶性白质脑病(progressive multifocal leukoencephalopathy,PML) 是一种由多瘤病毒属JC病毒(John Cunningham virus,JCV)再激活导致的中枢神经系统严重局灶性脱髓鞘性疾病[1-2]。初次感染JC病毒多发生在儿童期,导致大多数个体处于慢性无症状带菌状态,病毒多数潜...
Patients with progressive multifocal leukoencephalopathy (PML), which is caused by the JC virus, can be successfully treated using cryopreserved BK-virus-specific T cells, new research suggests. Investigators treated three patients with PML using an infusion of ex vivo–expanded, partially HLA-matched...
Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system that is caused by reactivation of the polyoma virus JC (JC virus). Asymptomatic primary infection with JC virus occurs in childhood and antibodies can be found in 86% of adults. In mos...
Background PML is a demyelinating disease caused by JC virus (JCV) reactivation in advanced HIV persons. No specific treatment has demonstrated efficacy in improving outcomes. Recent findings showed conflicting evidence on the response of PML lesions after treatment with checkpoint inhibitors, including ...
Not a Disease of the Past: A Case Series of Progressive Multifocal Leukoencephalopathy in the Established Antiretroviral Era 2019, AIDS Research and Human Retroviruses John Cunningham virus: An overview on biology and disease of the etiological agent of the progressive multifocal leukoencephalopathy 2018,...
Progressive multifocal leukoencephalopathy (PML) is a deadly brain disease caused by the polyomavirus JC (JCV). The aim of this study is to develop 'designer T cells' armed with anti-JCV TCR-based chimeric immune receptors (CIRs) by gene modification for PML immunotherapy. Two T cell lines sp...
国外学者 [1]对1994年至2019年文献报告中提到的94例病例汇总分析显示HIV感染所致PML占89%，其主要致病病毒为乳头多瘤空泡病毒(JC poly-omavirus，JCV)。HIV-PML患者1~2年死亡率高(80%以上)，预后非常差[2]。现报告一例误诊病例。1 病例介绍 患者男，48岁。主因“言语不清10天，加重伴左右不识3天”就诊...
Progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease caused by JC virus (JCV) infection of oligodendrocytes, may develop in pati... G Leonid,R Carl,T Manuela,... - 《Journal of Infectious Diseases》 被引量: 155发表: 0年 JC virus (JCV) genotypes in brain tissue fr...