Polyomavirus JC (JCV) has been implicated in the etiology of multiple sclerosis (MS), because it causes progressive multifocal leukoencephalopathy (PML), a multifocal demyelinating disease with many microscopal similarities to MS. During childhood, the virus establishes a latent infection in the ...
The emergence of biologic therapies for autoimmune diseases such as lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, ankylosing spondylitis, and Crohn’s disease has put these patients at risk for JC virus–related complications as well. There have been reports of PML associated with the ...
This suggests that among the patients with smaller, less classical MRI features, relied-on laboratory test results may not be immediately able to confirm a PML diagnosis. At first approximation, such conclusions seem axiomatic, smaller lesion, less virus. However, understanding how JCV...
Chinese Strains (Type 7) of JC Virus Are Afro-Asiatic in Origin But Are Phylogenetically Distinct from the Mongolian and Indian Stra... JC-virus seroconversion in multiple sclerosis patients receiving natalizumab. Fatal PML associated with efalizumab therapy: Insights into integrin αLβ2 in JC vir...
on the surface of B cells, causing their depletion from peripheral circulation by activating the complement cascade. During the clinical trial of Tysabri, PML has been diagnosed in two multiple sclerosis patients and in one Crohn’s patient [7,9,10]. As of March 1, 2012, 212 PML cases ass...
The reactivation of the virus in immunosuppressed patients provokes a migration of the virus to the central nervous system and a lytic infection of neural cells. Progressive multifocal leucoencephalopathy (PML) is the most common JCV-induced brain disease and caused by infection of glial cells. ...
We suspect that his clinical presentation was mostly mediated by JC virus replication; however, we considered IRIS as a differential diagnosis. IRIS associated to PML has been well described within the HIV population. His clinical worsening despite the control of his HIV infection was suggestive of...
Most adults who are infected with the JC virus, the etiologic agent in PML, do not ha... Y Chen,E Bord,T Tompkins,... - 《New England Journal of Medicine》 被引量: 187发表: 2009年 Immune responses to JC virus in patients with multiple sclerosis treated with natalizumab: a cross-...
have been infected by the John Cunningham Virus (JCV). JCV is a common virus that can cause PML in people who have weakened immune systems, such as people taking TYSABRI. Before or while you receive TYSABRI, your doctor may do a blood test to check if you have been infected by JCV ...
being the proven causative agent of the progressive multifocal leukoencephalopathy (PML) in individuals with highly suppressed immune system function, especially in the context of HIV/AIDS or patients receiving immunomodulatory therapies for diseases as multiple sclerosis (Dalianis and Hirsch, 2013; De Ga...