The article reports on a pilot study conducted by U.S.-based researchers which suggests that urinary JC virus DNA can be a marker for progressive multifocal leukoencephalopathy (PML). It has also revealed that some insights into viral replication can be found in monitoring for JC virus in the...
在本实施例中公开的结果表明,根据本发明的诱导型crispr系统可引起jcvt-ag的药物诱导型消融并减轻jcv感染的影响,而不会对类似的正常基因造成有害的脱靶效应。总之,所有前述实施例的结果表明,根据本发明的crispr系统对消除pml患者中的活跃复制jcv有用,从jcv的无症状宿主中除去潜在jcv,并且防止处于jcv风险中的未感染个体...
leukoencephal0pathy,PML)是一种由Jc病毒(JCV)感染少突 胶质细胞引起的致命性中枢神经系统脱髓鞘疾病。1958 年,美国麻省总医院的Richardson总结了2例慢性淋巴细胞 白血病及l例霍奇金病患者尸检中发现的特殊脑病理改变, 指出其白质内均存在众多大小不等的脱髓鞘病灶,而且小病 ...
GENE EDITING METHODS AND COMPOSITIONS FOR ELIMINATING RISK OF JC VIRUS ACTIVATION AND PML (PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY) DURING IMMUNOSUPPRESSIVE THERAPYA method of eliminating the risk of JCV activation in a subject undergoing immunosuppressive therapy, by administering an effective amount of a...
Jc Virus JC virus is the etiological agent of PML. The infectious nature of the disease was described in 1964 with the finding of virions within intranuclear inclusion bodies of oligodendrocytes.80 In 1971, the JC virus was isolated from the brain tissue and named after a patient with Hodgkin...
John Cunningham virus: An overview on biology and disease of the etiological agent of the progressive multifocal leukoencephalopathy 2018, New Microbiologica John Cunningham virus large T antigen detection in brain biopsy of an HIV-infected patient with glioblastoma multiforme: More than a coincidental ...
Once a rare disease primarily seen in patients with impaired immune systems due to lymphoproliferative and myeloproliferative disorders, PML has become one of the major neurologic problems among pat...Clifford, D. B., and E. O. Major. 2001. The biology of JC virus and progressive multifocal ...
rearrangement patternsThe JC virus (JCV) is generally considered the etiological agent of progressive multifocal leukoencephalopathy (PML), a demyelinating brain illness, often associated with immunosuppression and sign...doi:http://dx.doi.org/10.1080/jnv.9.6.603.611V Pietropaolo...
A 610-bp region of the JC virus (JCV) genome sequenced from brains of 11 progressive multifocal leukoencephalopathy (PML) patients contains 20 sites of point mutations that allow reliable classification of JCV isolates into two types. These type-determining sites were located in the region extending...
The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus Anti‐JC virus antibodies: Implications for PML Risk Stratification Prevalence of antibodies in human sera against JC virus, an isolate from a case of progressive multifocal leuk...