Programmed cell death 1 ligand 1 (PD-L1) is a ligand of programmed cell death 1 (PD-1) that functions as an immune checkpoint by down-regulating immune responses. To determine whether PD-L1 is a therapy target in vitiligo treatment, Pmel-1 vitiligo mice were treated with a PD-L1 fusion...
Nevertheless, in APP transgenic mice longer treatment durations (> 5 months) had a stronger effect on hair depigmentation; the proportion of the body with grey hair increased with prolonged treatment time, resulting ultimately in the appearance of a complete grey-colored mouse which is again in...
HNT-TCR转基因小鼠 1. To solve this problem, we adopted the HNT-TCR transgenic mice which have homogenous antige. 本文利用HNT-TCR转基因小鼠高度单一的针对HA多肽抗原的CD4+T细胞群体,以T细胞增殖反应作为检测方法,比较研究了克隆CD4+T细胞和新提取未经刺激的CD4+T细胞对无能诱导的反应。6...
J Exp Med 183: 1965–1971 Touloukian CE, Leitner WW, Topalian SL, Li YF, Robbins PF, Rosenberg SA and Restifo NP (2000) Identification of a MHC class II-restricted human gp 100 epitope using DR4-IE transgenic mice. J Immunol 164: 3535–3542 Tueting T, Wilson CC, Martin DM, ...