Furthermore, Tregs abundance was also increased in both the spleen and circulation of Pmel-1 mice treated with PD-L1. These data indicate that PD-L1 protein therapy inhibits the immune response and reverses depigmentation development in Pmel-1 vitiligo mice....
pmel-1这个基因特异于人SILV（gp100）的小鼠同源物（pmel-17），是一种由大多数恶性黑素瘤细胞（包括...
可以上NCBI上搜索一下，这个细胞的前面PMEL1是一个基因的名字，我猜测这可能是一种表达这个基因的T细胞...
Programmed cell death 1 ligand 1 (PD-L1) is a ligand of programmed cell death 1 (PD-1) that functions as an immune checkpoint by down-regulating immune responses. To determine whether PD-L1 is a therapy target in vitiligo treatment, Pmel-1 vitiligo mice
9 In mice, the allele Mitfmi leads to complete absence of melanocytes in the homozygous state,10 while mice homozygous for Mitfvit (vitiligo) are born with a nearly normal coat color, but turn white over the first few months of life as melanocytes are lost, suggesting a role for MITF in...
Naïve B16 specific Pmel-1 T cells are primed by tumor growth and infiltrate tumors after adoptive transfer into tumor bearing mice.David, A. SchaerYongbiao, LiTaha, MerghoubGabrielle, A. RizzutoAmos, ShemeshAdam, D. CohenYanyun, Li
这篇文章的材料方法部分有说明，pmel-1 thy1.1+ T cell来自pmel-1转基因小鼠。这个小鼠是携带pmel-1...
可能和OT-1 mice sacrifice 得到的OT-1 T 细胞一样？PMELCD8+ T细胞能够特异性识别黑色素瘤B16F10...