stem cellsyolk sacSignificant progress has been made towards a better understanding of the establishment of hematopoiesis in the embryo. Hematopoietic precursors have been shown to arise independently in the yolk sac and in the intra-embryonic mesoderm. From the combined analysis of differentiation ...
一些干细胞,又被称为多能细胞(pluripotent cells),可以特化为多种不同种类的细胞。例如从胚胎提取的多能细胞,可以被 … mjmk-acg.blogbus.com|基于6个网页 2. 骨髓多能细胞 骨髓多能细胞(Pluripotent cells)造血干细胞(hematopoietic stem cells ,HSCs)间叶干细胞(mesenchymal stem cells)HS… ...
Pluripotent hematopoietic stem cells thus differentiate into bone marrow as myeloid or lymphoid stem cells. Myeloid stem cells give rise to a second level of lineage-specific CFU cells that go on to produce neutrophils, monocytes, eosinophil...
A developmental route to hematopoietic stem cells A differentiation method informed by developmental biology converts human pluripotent stem cells to engraftable hematopoietic stem and progenitor cells without the use of transgenes. Adam C. Wilkinson ...
Human ES (H1, H9) and iPS (STiPS-M001, WLS-1C) cell lines maintained in mTeSR™1 (daily feeds) or mTeSR™ Plus (restricted feeds) were differentiated to hematopoietic progenitor cells using the STEMdiff™ Hematopoietic Kit. At the end of the differentiation period, cells were harvested...
The overall significance of studying the role of non-coding RNA lies in the fact that it will help modulate the hematopoietic pathways and eventually be used for therapeutic purposes. 展开 关键词: Cellular biology Hematopoietic development from adult human embryonic stem cells and induced pluripotent ...
Aberrant inflammation in the CNS has been implicated as a major player in the pathogenesis of human neurodegenerative disease. We developed a new approach to derive microglia from human pluripotent stem cells (hPSCs) and built a defined hPSC-derived tri-culture system containing pure populations of ...
To resolve these issues, researchers have been mounting considerable efforts to induce HSCs from autologous sources, such as induced-pluripotent stem cells, hematopoietic precursors, and fibroblasts. Human pluripotent stem cells (hPSCs) are an intriguing platform that allows for large-scale expansion ...
The present report describes the bulk isolation of pluripotent stem cells (PSC) (assayed as day-9 CFU-S, colony-forming-units-spleen). As starting material, spleens, highly enriched with PSC, were used from mice that were bled and treated with thiamphenicol (TAP). In subjecting the spleen...
Stem Cells Pluripotent stem cells can be derived from the inner cell mass of a blastocyst (an early-stage embryo), termed embryonic stem (ES) cells, or induced from somatic cells by ectopic expression of a set of transcription factors including Oct3/4, Sox2, c-Myc, Klf4, Nanog, named iP...