Diagram representing the feeder-free and serum-free erythroid differentiation of iPSCs. Abbreviations: BMP, bone morphogenic protein; EB, embryoid body; EPO, erythropoietin; FGF, fibroblast growth factor; HC, hydrocortisone; iPSC, induced pluripotent stem cells; IBMX, isobutylmethyl xanthine; IGF, in...
6 Dissection of chemical reprogramming from human somatic cells to pluripotent stem cells. a, Schematic diagram of single-cell RNA-sequencing analysis strategy during chemical reprogramming. b, UMAP layout visualization of single-cell RNA-sequencing profiles of chemical reprogramming process from hADSCs ...
Figure 5. Schematic diagram representing hepatic differentiation in vivo correlated to in vitro differentiation of human pluripotent stem cells. Liver development in vivo and hepatocyte differentiation in vitro are depicted with examples of gene expression associated with each developmental or differentiation ...
Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration and impose a considerable economic burden on patients and society, making efforts to cure blindness imperative. Transgenic animals mimicking human genetic diseases
Dysfunction of pancreatic δ cells contributes to the etiology of diabetes. Despite their important role, human δ cells are scarce, limiting physiological studies and drug discovery targeting δ cells. To date, no directed δ-cell differentiation method
They demonstrated differentiation ability into several cell types: neurons, astrocytes, melanocytes, smooth muscle cells, osteoblasts, adipocytes and chondrocytes. Furthermore, they could be induced to differentiate into induced mesenchymal stem cells (iMSCs) which retain the essential functions of somatic...
The present invention relates to methods of detecting, in a sample, embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cell
A prominent method to generate T cells is an in vitro system via co-culture of either mouse or human hematopoietic stem/progenitors (HSPCs) with stromal cell lines expressing the Notch ligand, such as OP9-DL1/DL4 or 3D-based MS5-hDLL1/4.1,2,3Despite the great contribution of this appro...
Human induced pluripotent stem cells (CBiPSC2: human cord blood derived induced pluripotent stem cell clone 2, reprogrammed from cord blood derived endothelial cells (18); HD2-iPSC: healthy donor derived iPSC clone 2, reprogrammed from human skin fibroblasts (not published); PMM2-iPSC: ...