induced pluripotent stem cellsreprogrammingThe generation of hematopoietic stem cells (HSCs) from induced pluripotent stem cells (iPSCs) is an active and promising area of research; however, generating engraftable HSCs remains a major obstacle. ex vivo HSC derivation from renewable sources such as ...
摘要: Aspects of hematopoietic stem cells differentiation from human pluripotent stem cells 大澤 光次郎 血液内科 63(3), 344-347, 2011-09关键词: embryonic stem cells (ESCs induced pluripotent stem cells (iPSCs hematopoietic stem cells (HSCs direct reprogramming 年份: 2011 ...
Human pluripotent stem cells (hPSCs) are an intriguing platform that allows for large-scale expansion culture and correction of mutations. Achieving the formation of HSCs from hPSCs would transform our ability to model and treat hematologic disease from autologous stem cells. Desired cell types have ...
The differentiation of human pluripotent stem cells (PS cells) into repopulating hematopoietic stem cells (HSCs) could provide novel therapeutic options for a range of hematopoietic disorders. For example, HSCs derived from patient induced PS cells (iPS cells)1could circumvent the donor–host mismatch...
rates. Relapse rates with autologous hematopoietic stem cell transplantation are higher because there is no graft-vs-tumor effect and because circulating tumor cells may be inadvertently collected with stem cells and transplanted. Ex vivo tumor cell purging before autologous transplantation is un...
Hematopoietic and Endothelial Differentiation of Human Induced Pluripotent Stem Cells. Stem Cells. 2009; 27: 559-567.Choi KD, Yu J, Smuga-Otto K, et al. Hematopoietic and en- dothelial differentiation of human induced pluripotent stem cells. Stem Cells 2009; 27:559-567....
Hematopoietic stem cells (HSCs) are excellent targets for gene therapy due to the relative ease with which they can be manipulated and their ability to repopulate the entire hematopoietic system for the life of a patient. The HSC must be permissive for transduction by the proposed vector; the ...
We have studied several features of pluripotent hematopoietic stem cells (PHSC) and day-12 spleen colony-forming units (CFU-S12) in murine bone marrow. C57BL/6J marrow cell suspensions were separated by elutriation and fractions were obtained at flow rates (FR) of 25 ml/min, 29/30 ml/min...
Human pluripotent stem cells (PSCs) have the potential to provide an inexhaustible source of hematopoietic stem cells (HSCs) that could be used in disease modeling and in clinical applications such as transplantation. Although the goal of deriving definitive HSCs from PSCs has not been achieved, ...
Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) play a pivotal role in maintaining lifelong hematopoiesis. The distinction between stem cells and other progenitors, as well as the assessment of their functions, has long been a central focus in stem cell research. In recent years...