Human pluripotent stem cells as a scalable source for limbal stem cells ‐ From basic biology towards clinical applicationsThere is an unmet clinical need to treat especially bilateral limbal stem cell deficiency (LSCD). For this allogeneic source of limbal stem cells (LSCs) differentiated from ...
In this study, we generated alveolar organoids (AOs) derived from human pluripotent stem cells (hPSCs) for use as an PF model and for drug efficacy evaluation. Stepwise direct differentiation of hPSCs into alveolar epithelial cells by mimicking developmental cues in a temporally controlled manner ...
Human pluripotent stem-cell-derived islets (hPSC-islets) are a promising cell resource for diabetes treatment1,2. However, this therapeutic strategy has not been systematically assessed in large animal models physiologically similar to humans, such as no
Induced pluripotent stem cell, immature cell that is generated from an adult (mature) cell and that has regained the capacity to differentiate into any type of cell in the body. Induced pluripotent stem cells were first described in 2006. Learn about the
In the present study, we generate ZZUNEUi022-A, a urine cells-derived induced pluripotent stem cell (iPSC) line, from a 29-year-old healthy male via Sendai virus delivery system. ZZUNEUi022-A showed stable karyotype, and could differentiate into three germ layers (ectoderm, mesoderm, and ...
Here, we successfully revascularized and repopulated a large, full-thickness portion of a ventricle using human induced pluripotent stem cell-derived endothelial and cardiac cells. At 60 days, histologic studies showed that the microanatomical organization and cellular composition of this region was ...
clinical labs. ScienCell Research Laboratories has developed a wide variety of cell-based assay kits to facilitate research in many areas such as metabolism, oxidative stress, and stem cells as well as to provide quantitative results for enzyme activity, metabolite level, and the status of cell ...
BMC Cell Biology volume 11, Article number: 72 (2010) Cite this article 7918 Accesses 39 Citations 4 Altmetric Metrics details Abstract Background Induced pluripotent stem (iPS) cells are the novel stem cell population induced from somatic cells. It is anticipated that iPS will be used in the...
induced pluripotent stem cells (iPSCs) hold great potential to aid in the preservation of threatened animal populations. For endangered species, such as the northern white rhinoceros (Ceratotherium simum cottoni), supply of embryos is often limited. After the death of the last male in 2019, on...
Human induced pluripotent stem cells (iPSCs) are used to generate models of human diseases that recapitulate the pathogenic process as it occurs in affected cells. Many differentiated cell types can currently be obtained from iPSCs, but no validated protocol is yet available to specifically generate...