Gastric Kappa-Restricted Plasma-Cell Neoplasm: Diagnosed on Routine Endoscopic Evaluation: 929Jafri, RizwanSapp, AbbyNawaz, MustafaYarbrough, AlexOfficial journal of the American College of Gastroenterology | ACG
CD138, syndecan-1; H&E, hematoxylin and eosin; kappa, light chain kappa; lambda, light chain lambda; MM, multiple myeloma; MUM1, multiple myeloma; MyoD1, myoblast determination protein 1; NIFTP, noninvasive follicular thyroid neoplasm with papillary-like nuclear features; P53, tumor protein ...
Mantle cell lymphoma is a mature lymphoid neoplasm characterized by the t(11;14)(q13;q32) and cyclin D1 overexpression. SOX11 is a transcription factor commonly overexpressed in these tumors but absent in most other mature B-cell lymphomas whose function
PLASMA CELL DYSCRASIAS MULTIPLE MYELOMA (MM) DEFINITION • This is due to monoclonal proliferation of the antibody-producing plasma B cells with an associated increased production of a single immunoglobulin • It is the most common primary malignant neoplasm of bone and is the predominantplasma ce...
Switzerland; 6Department of Pathology, Hospital del Mar, Autonomous University of Barcelona, Barcelona, Spain and 7Department of Histopathology, Royal Marsden Hospital, London, UK Mantle cell lymphoma is a mature lymphoid neoplasm characterized by the t(11;14)(q13;q32) and cyclin D1 overexpression...
The liver can be infiltrated in lymphoplasmacytic lymphoma (LPL), a neoplasm of small B lymphocytes, plasmacytoid lymphocytes, and plasma cells, a disease usually involving bone marrow and less commonly lymph nodes and inner organs. LPL is often associated with production of a paraprotein, usually...
the monotypic plasma cells had the distinctive, Waldenstro¨m's macroglobulinemia/lymphoplas- bright CD38 and CD138 coexpression typically seen macytic lymphoma is often described as a neoplasm in true plasma cell neoplasms such as multiple of 'small lymphocytes, plasmacytoid lymphocytes, myeloma (...
electrophoresis and immunofixation results were obtained, the 2 amyloid cases showed evidence of serum or urine paraproteins: serum IgM kappa in a patient with kappa light chain-restricted plasma cell neoplasm and urine IgA lambda in a patient with lambda light chain-restricted plasma cell neoplasm...
Serum protein electrophoresis demonstrated IgG lambda paraproteinemia, with a serum-free light chain kappa-to-lambda ratio of 0.074. A skeletal survey revealed the presence of lytic lesions. Bone marrow investigations confirmed the presence of lambda-light-chain-restricted clonal plasma c...
One plasma cell produces one type of immunoglobulin (for instance, IgA kappa or IgG kappa). In the case of plasma cell dyscrasia, the monoclonal malignant plasma cells all produce the same immunoglobulin. This monoclonal immunoglobulin is referred to as M-protein or paraprotein which usually ...