Gastric Kappa-Restricted Plasma-Cell Neoplasm: Diagnosed on Routine Endoscopic Evaluation: 929Jafri, RizwanSapp, AbbyNawaz, MustafaYarbrough, AlexOfficial journal of the American College of Gastroenterology | ACG
Subsequent bone marrow biopsy showed 15% kappa-restricted plasma cells. Multiple myeloma was diagnosed, and chemotherapy initiated. With decrease in kappa light chain burden. kidney function improved, and patient was able to come off dialysis. Conclusion: This case describes a rare presentation of ...
Cells positive for either the kappa opioid receptor or both the kappa opioid receptor and preprodynorphin were restricted to the vasopressin expressing neuronal population and not found in the oxytocin expressing neuronal population. The kappa opioid receptor and dynorphin were examined in the posterior...
2). Although often used as a surrogate marker of clonality, light chain restriction has been reported in nonclonal reactive B-cell populations [17]. For example, lambda immunoglobulin light chain restricted nonclonal populations have been identified in tonsillar specimens during childhood [18] and ...
Immunoglobulins (Ig) secreted from a plasma cell contain either kappa or lambda light chains, but not both. This phenomenon is termed isotypic kappa-lambda exclusion. While kappa-producing cells have their lambda chain genes in germline configuration, in most lambda-producing cells the kappa chain...
Macrophage-restricted expression of Ncf1 did not restored arthritis resistance in T cell-independent anti-collagen antibody-induced arthritis model, however restored arthritis resistance in collagen induced arthritis model. Furthermore, suppressed T cell activation was found in Ncf1-deficient mice upon ...
multiple myeloma (MM), incurability remains an ongoing clinical challenge1. MM is characterised by the expansion of malignant monoclonal plasma cells (PCs) within the bone marrow (BM), and production of excess monoclonal immunoglobulin (M protein) and/or isotype-restricted free light chains (FLC)...
Thus, a course of plasticity induced by tDCS is still relatively restricted, advanced stimulation protocols are needed. Methods: For identifying pathological plasticity alterations in schizophrenia, tDCS was applied to the motor cortex of patients and healthy controls. tDCS-induced alterations of cortical...
Understanding which opioid receptors are expressed in which types of peripheral sensory neurons is important because this insight may inform the clinical use of peripherally restricted agonists. In the present study, we used the combination of a KOR-cre allele, viral tracing, single-cell RT-PCR, ...
V3-glycan targeting bnAbs are of high interest because they are common and not restricted by certain germline genes4,6,8,10,12,19. BF520.1 is of particular interest because it developed more rapidly than adult V3-bnAbs. Our study of this infant bnAb’s evolution suggests it achieved broad ...