Gastric Kappa-Restricted Plasma-Cell Neoplasm: Diagnosed on Routine Endoscopic Evaluation: 929Jafri, RizwanSapp, AbbyNawaz, MustafaYarbrough, AlexOfficial journal of the American College of Gastroenterology | ACG
Formed in 2014, HaemaLogiX is a public unlisted biotech company researching antibody therapies for multiple myeloma. Multiple myeloma is a haematological (blood) cancer of plasma cells (B cells) that can cause focused damage to a patient’s bone marrow. Multiple myeloma is considered treatable but...
Subsequent bone marrow biopsy showed 15% kappa-restricted plasma cells. Multiple myeloma was diagnosed, and chemotherapy initiated. With decrease in kappa light chain burden. kidney function improved, and patient was able to come off dialysis. Conclusion: This case describes a rare presentation of ...
Cells positive for either the kappa opioid receptor or both the kappa opioid receptor and preprodynorphin were restricted to the vasopressin expressing neuronal population and not found in the oxytocin expressing neuronal population. The kappa opioid receptor and dynorphin were examined in the posterior...
A pure population of light chain restricted B-cells is easy to recognize using flow cytometric immunophenotyping and is usually reflected in an abnormal kappa/lambda ratio. However, evaluation of the kappa to lambda ratio will not identify small clonal populations admixed with reactive polyclonal B-...
Plasma cells do not produce IgG (other isotypes are normal) Anti-polysaccharide Ab deficiency ? Plasma cells do not produce Ab to polysaccharides in capsules of bacteria HIGM syndromes AID, CD40,?, UNG, NEMO Plasma cells produce normal IgM but decreased amounts of all other isotypes due to...
Immunoglobulins (Ig) secreted from a plasma cell contain either kappa or lambda light chains, but not both. This phenomenon is termed isotypic kappa-lambda exclusion. While kappa-producing cells have their lambda chain genes in germline configuration, in most lambda-producing cells the kappa chain...
multiple myeloma (MM), incurability remains an ongoing clinical challenge1. MM is characterised by the expansion of malignant monoclonal plasma cells (PCs) within the bone marrow (BM), and production of excess monoclonal immunoglobulin (M protein) and/or isotype-restricted free light chains (FLC)...
Expression of opioid receptor transcripts was restricted to subpopulations of neurons within most regions studied demonstrating differences in the cellular expression patterns of mu, kappa, and delta opioid receptor messenger RNAs in numerous brain regions. The messenger RNA distribution patterns for each ...
Interestingly, constitutive KOR KO mice show equivalent levels of footshock-potentiated startle compared to wild type littermates, whereas KOR deletion restricted to DAT expressing neurons (DATCre KO) was sufficient to reduce potentiated startle following the first two blocks of footshock. This ...